SERPINI2

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Serpin peptidase inhibitor, clade I (pancpin), member 2
Identifiers
Symbol(s) SERPINI2; MEPI; PANCPIN; PI14; TSA2004
External IDs OMIM: 605587 MGI: 1915181 HomoloGene: 21248
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 5276 67931
Ensembl ENSG00000114204 ENSMUSG00000034139
Uniprot O75830 Q4G0D3
Refseq NM_006217 (mRNA)
NP_006208 (protein)		 NM_026460 (mRNA)
NP_080736 (protein)
Location Chr 3: 168.64 - 168.67 Mb Chr 3: 75.33 - 75.36 Mb
Pubmed search [1] [2]

Serpin peptidase inhibitor, clade I (pancpin), member 2, also known as SERPINI2, is a human gene.[1]

The protein encoded by this gene is a member of the serine protease inhibitor (serpin) superfamily made up of proteins which play central roles in the regulation of a wide variety of physiological processes, including coagulation, fibrinolysis, development, malignancy and inflammation. The gene product may have a role in a growth-control, possibly growth-suppressing pathway and, when impaired, may be involved in pancreatic carcinogenesis. The protein is a member of the plasminogen activator inhibitor-1 family, a subset of the serpin superfamily whose members act as tissue-specific tPA inhibitors. Two alternatively spliced transcript variants encoding distinct protein isoforms have been found for this gene.[1]

[edit] References

  1. ^ a b Entrez Gene: SERPINI2 serpin peptidase inhibitor, clade I (pancpin), member 2.

[edit] Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149. 
  • Ozaki K, Nagata M, Suzuki M, et al. (1998). "Isolation and characterization of a novel human pancreas-specific gene, pancpin, that is down-regulated in pancreatic cancer cells.". Genes Chromosomes Cancer 22 (3): 179–85. PMID 9624529. 
  • Xiao G, Liu YE, Gentz R, et al. (1999). "Suppression of breast cancer growth and metastasis by a serpin myoepithelium-derived serine proteinase inhibitor expressed in the mammary myoepithelial cells.". Proc. Natl. Acad. Sci. U.S.A. 96 (7): 3700–5. PMID 10097100. 
  • Chang WS, Chang NT, Lin SC, et al. (2000). "Tissue-specific cancer-related serpin gene cluster at human chromosome band 3q26.". Genes Chromosomes Cancer 29 (3): 240–55. PMID 10992299. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
  • Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.". Cell 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. 
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