SEMG2

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Semenogelin II
Identifiers
Symbol(s) SEMG2; SGII
External IDs OMIM: 182141 HomoloGene: 88473
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 6407 n/a
Ensembl ENSG00000124157 n/a
Uniprot Q02383 n/a
Refseq NM_003008 (mRNA)
NP_002999 (protein)		 n/a (mRNA)
n/a (protein)
Location Chr 20: 43.28 - 43.29 Mb n/a
Pubmed search [1] n/a

Semenogelin II, also known as SEMG2, is a human gene.[1]

The secreted protein encoded by this gene is involved in the formation of a gel matrix that encases ejaculated spermatozoa. Proteolysis by the prostate-specific antigen (PSA) breaks down the gel matrix and allows the spermatozoa to move more freely. The encoded protein is found in lesser abundance than a similar semenogelin protein. The genes encoding these two semenogelin proteins are found in a cluster on chromosome 20.[1]

[edit] References

  1. ^ a b Entrez Gene: SEMG2 semenogelin II.

[edit] Further reading

  • Ulvsbäck M, Lazure C, Lilja H, et al. (1992). "Gene structure of semenogelin I and II. The predominant proteins in human semen are encoded by two homologous genes on chromosome 20.". J. Biol. Chem. 267 (25): 18080–4. PMID 1517240. 
  • Lilja H, Lundwall A (1992). "Molecular cloning of epididymal and seminal vesicular transcripts encoding a semenogelin-related protein.". Proc. Natl. Acad. Sci. U.S.A. 89 (10): 4559–63. PMID 1584792. 
  • Schneider K, Kausler W, Tripier D, et al. (1989). "[Isolation and structure determination of two peptides occurring in human seminal plasma]". Biol. Chem. Hoppe-Seyler 370 (4): 353–6. PMID 2757795. 
  • Lundwall A (1996). "The structure of the semenogelin gene locus--nucleotide sequence of the intergenic and the flanking DNA.". Eur. J. Biochem. 235 (3): 466–70. PMID 8654389. 
  • Malm J, Hellman J, Magnusson H, et al. (1996). "Isolation and characterization of the major gel proteins in human semen, semenogelin I and semenogelin II.". Eur. J. Biochem. 238 (1): 48–53. PMID 8665951. 
  • Kise H, Nishioka J, Kawamura J, Suzuki K (1996). "Characterization of semenogelin II and its molecular interaction with prostate-specific antigen and protein C inhibitor.". Eur. J. Biochem. 238 (1): 88–96. PMID 8665956. 
  • Bjartell A, Malm J, Moller C, et al. (1997). "Distribution and tissue expression of semenogelin I and II in man as demonstrated by in situ hybridization and immunocytochemistry.". J. Androl. 17 (1): 17–26. PMID 8833737. 
  • Ulvsbäck M, Lundwall A (1997). "Cloning of the semenogelin II gene of the rhesus monkey. Duplications of 360 bp extend the coding region in man, rhesus monkey and baboon.". Eur. J. Biochem. 245 (1): 25–31. PMID 9128720. 
  • Peter A, Lilja H, Lundwall A, Malm J (1998). "Semenogelin I and semenogelin II, the major gel-forming proteins in human semen, are substrates for transglutaminase.". Eur. J. Biochem. 252 (2): 216–21. PMID 9523691. 
  • Lövgren J, Airas K, Lilja H (1999). "Enzymatic action of human glandular kallikrein 2 (hK2). Substrate specificity and regulation by Zn2+ and extracellular protease inhibitors.". Eur. J. Biochem. 262 (3): 781–9. PMID 10411640. 
  • Malm J, Hellman J, Hogg P, Lilja H (2000). "Enzymatic action of prostate-specific antigen (PSA or hK3): substrate specificity and regulation by Zn(2+), a tight-binding inhibitor.". Prostate 45 (2): 132–9. PMID 11027412. 
  • Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052. 
  • Brillard-Bourdet M, Réhault S, Juliano L, et al. (2002). "Amidolytic activity of prostatic acid phosphatase on human semenogelins and semenogelin-derived synthetic substrates.". Eur. J. Biochem. 269 (1): 390–5. PMID 11784334. 
  • Lundwall A, Bjartell A, Olsson AY, Malm J (2003). "Semenogelin I and II, the predominant human seminal plasma proteins, are also expressed in non-genital tissues.". Mol. Hum. Reprod. 8 (9): 805–10. PMID 12200457. 
  • Ek P, Malm J, Lilja H, et al. (2003). "Exogenous protein kinases A and C, but not endogenous prostasome-associated protein kinase, phosphorylate semenogelins I and II from human semen.". J. Androl. 23 (6): 806–14. PMID 12399526. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Yoshida K, Yamasaki T, Yoshiike M, et al. (2004). "Quantification of seminal plasma motility inhibitor/semenogelin in human seminal plasma.". J. Androl. 24 (6): 878–84. PMID 14581514. 
  • Jensen-Seaman MI, Li WH (2004). "Evolution of the hominoid semenogelin genes, the major proteins of ejaculated semen.". J. Mol. Evol. 57 (3): 261–70. doi:10.1007/s00239-003-2474-x. PMID 14629036. 
  • Dorus S, Evans PD, Wyckoff GJ, et al. (2005). "Rate of molecular evolution of the seminal protein gene SEMG2 correlates with levels of female promiscuity.". Nat. Genet. 36 (12): 1326–9. doi:10.1038/ng1471. PMID 15531881. 
  • Jonsson M, Linse S, Frohm B, et al. (2005). "Semenogelins I and II bind zinc and regulate the activity of prostate-specific antigen.". Biochem. J. 387 (Pt 2): 447–53. doi:10.1042/BJ20041424. PMID 15563730. 
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