Selenophosphate synthetase 1

From Wikipedia, the free encyclopedia

Identifiers

SEPHS1; SPS1; SPS; MGC4980; SELD

External IDs

OMIM: 600902 MGI: 1923580 HomoloGene: 56558

Gene ontology
Molecular Function:	• nucleotide binding • catalytic activity • selenide, water dikinase activity • ATP binding • GTP binding • selenium binding • transferase activity
Biological Process:	• protein modification process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_012247 (mRNA)
NP_036379 (protein)

NM_175400 (mRNA)
NP_780609 (protein)

Location

Chr 10: 13.4 - 13.43 Mb

Chr 2: 4.8 - 4.83 Mb

Pubmed search

[1]

[2]

Selenophosphate synthetase 1, also known as SEPHS1, is a human gene.^[1]

This protein encodes an enzyme that synthesizes selenophosphate from selenide and ATP. Selenophosphate is the selenium donor used to synthesize selenocysteine, which is co-translationally incorporated into selenoproteins at in-frame UGA codons.^[1]

[edit] References

^ ^a ^b Entrez Gene: SEPHS1 selenophosphate synthetase 1.

[edit] Further reading

Low SC, Harney JW, Berry MJ (1995). "Cloning and functional characterization of human selenophosphate synthetase, an essential component of selenoprotein synthesis.". J. Biol. Chem. 270 (37): 21659–64. PMID 7665581.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Tamura T, Yamamoto S, Takahata M, et al. (2004). "Selenophosphate synthetase genes from lung adenocarcinoma cells: Sps1 for recycling L-selenocysteine and Sps2 for selenite assimilation.". Proc. Natl. Acad. Sci. U.S.A. 101 (46): 16162–7. doi:10.1073/pnas.0406313101. PMID 15534230.
Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome.". Cell 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Saiki R, Nagata A, Kainou T, et al. (2005). "Characterization of solanesyl and decaprenyl diphosphate synthases in mice and humans.". FEBS J. 272 (21): 5606–22. doi:10.1111/j.1742-4658.2005.04956.x. PMID 16262699.
Chung HJ, Yoon SI, Shin SH, et al. (2006). "p53-Mediated enhancement of radiosensitivity by selenophosphate synthetase 1 overexpression.". J. Cell. Physiol. 209 (1): 131–41. doi:10.1002/jcp.20714. PMID 16786570.