SECTM1

From Wikipedia, the free encyclopedia

Secreted and transmembrane 1

Identifiers

External IDs

OMIM: 602602 MGI: 2384805 HomoloGene: 86740

Gene ontology
Molecular Function:	• signal transducer activity • cytokine activity
Cellular Component:	• extracellular space • Golgi apparatus • membrane • integral to membrane
Biological Process:	• immune response • mesoderm development • positive regulation of I-kappaB kinase/NF-kappaB cascade

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_003004 (mRNA)
NP_002995 (protein)

NM_145373 (mRNA)
NP_663348 (protein)

Location

Chr 17: 77.87 - 77.88 Mb

Chr 11: 120.88 - 120.9 Mb

Pubmed search

[1]

[2]

Secreted and transmembrane 1, also known as SECTM1, is a human gene.^[1]

This gene encodes a transmembrane and secreted protein with characteristics of a type 1a transmembrane protein. It is found in a perinuclear Golgi-like pattern and thought to be involved in hematopoietic and/or immune system processes.^[1]

[edit] References

^ ^a ^b Entrez Gene: SECTM1 secreted and transmembrane 1.

[edit] Further reading

Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55-65. doi:10.1101/gr.4039406. PMID 16344560.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Matsuda A, Suzuki Y, Honda G, et al. (2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways.". Oncogene 22 (21): 3307-18. doi:10.1038/sj.onc.1206406. PMID 12761501.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Lyman SD, Escobar S, Rousseau AM, et al. (2000). "Identification of CD7 as a cognate of the human K12 (SECTM1) protein.". J. Biol. Chem. 275 (5): 3431-7. PMID 10652336.
Slentz-Kesler KA, Hale LP, Kaufman RE (1998). "Identification and characterization of K12 (SECTM1), a novel human gene that encodes a Golgi-associated protein with transmembrane and secreted isoforms.". Genomics 47 (3): 327-40. doi:10.1006/geno.1997.5151. PMID 9480746.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298.