SEC61B

From Wikipedia, the free encyclopedia

Sec61 beta subunit

Identifiers

External IDs

OMIM: 609214 MGI: 1913462 HomoloGene: 38229

Gene ontology
Molecular Function:	• protein transmembrane transporter activity
Cellular Component:	• endoplasmic reticulum • membrane • integral to membrane
Biological Process:	• protein targeting • protein transport

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_006808 (mRNA)
NP_006799 (protein)

NM_024171 (mRNA)
NP_077133 (protein)

Location

Chr 9: 101.02 - 101.03 Mb

Chr 4: 47.5 - 47.5 Mb

Pubmed search

[1]

[2]

Sec61 beta subunit, also known as SEC61B, is a human gene.^[1]

The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. Oligomers of the Sec61 complex form a transmembrane channel where proteins are translocated across and integrated into the ER membrane. This complex consists of three membrane proteins- alpha, beta, and gamma. This gene encodes the beta-subunit protein. The Sec61 subunits are also observed in the post-ER compartment, suggesting that these proteins can escape the ER and recycle back. There is evidence for multiple polyadenylated sites for this transcript.^[1]

[edit] References

^ ^a ^b Entrez Gene: SEC61B Sec61 beta subunit.

[edit] Further reading

Hartmann E, Sommer T, Prehn S, et al. (1994). "Evolutionary conservation of components of the protein translocation complex.". Nature 367 (6464): 654-7. doi:10.1038/367654a0. PMID 8107851.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298.
Wiertz EJ, Tortorella D, Bogyo M, et al. (1997). "Sec61-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction.". Nature 384 (6608): 432-8. doi:10.1038/384432a0. PMID 8945469.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149.
Knight BC, High S (1998). "Membrane integration of Sec61alpha: a core component of the endoplasmic reticulum translocation complex.". Biochem. J. 331 ( Pt 1): 161-7. PMID 9512475.
Chen Y, Le Cahérec F, Chuck SL (1998). "Calnexin and other factors that alter translocation affect the rapid binding of ubiquitin to apoB in the Sec61 complex.". J. Biol. Chem. 273 (19): 11887-94. PMID 9565615.
Kalies KU, Rapoport TA, Hartmann E (1998). "The beta subunit of the Sec61 complex facilitates cotranslational protein transport and interacts with the signal peptidase during translocation.". J. Cell Biol. 141 (4): 887-94. PMID 9585408.
Bebök Z, Mazzochi C, King SA, et al. (1998). "The mechanism underlying cystic fibrosis transmembrane conductance regulator transport from the endoplasmic reticulum to the proteasome includes Sec61beta and a cytosolic, deglycosylated intermediary.". J. Biol. Chem. 273 (45): 29873-8. PMID 9792704.
Greenfield JJ, High S (1999). "The Sec61 complex is located in both the ER and the ER-Golgi intermediate compartment.". J. Cell. Sci. 112 ( Pt 10): 1477-86. PMID 10212142.
Ingley E, Williams JH, Walker CE, et al. (1999). "A novel ADP-ribosylation like factor (ARL-6), interacts with the protein-conducting channel SEC61beta subunit.". FEBS Lett. 459 (1): 69-74. PMID 10508919.
Yamaguchi A, Hori O, Stern DM, et al. (2000). "Stress-associated endoplasmic reticulum protein 1 (SERP1)/Ribosome-associated membrane protein 4 (RAMP4) stabilizes membrane proteins during stress and facilitates subsequent glycosylation.". J. Cell Biol. 147 (6): 1195-204. PMID 10601334.
Meyer HA, Grau H, Kraft R, et al. (2000). "Mammalian Sec61 is associated with Sec62 and Sec63.". J. Biol. Chem. 275 (19): 14550-7. PMID 10799540.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9.". Nature 429 (6990): 369-74. doi:10.1038/nature02465. PMID 15164053.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Besemer J, Harant H, Wang S, et al. (2005). "Selective inhibition of cotranslational translocation of vascular cell adhesion molecule 1.". Nature 436 (7048): 290-3. doi:10.1038/nature03670. PMID 16015337.
Kim JE, Tannenbaum SR, White FM (2005). "Global phosphoproteome of HT-29 human colon adenocarcinoma cells.". J. Proteome Res. 4 (4): 1339-46. doi:10.1021/pr050048h. PMID 16083285.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635-48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Liao HJ, Carpenter G (2007). "Role of the Sec61 translocon in EGF receptor trafficking to the nucleus and gene expression.". Mol. Biol. Cell 18 (3): 1064-72. doi:10.1091/mbc.E06-09-0802. PMID 17215517.