SEC23A

From Wikipedia, the free encyclopedia

Sec23 homolog A (S. cerevisiae)

PDB rendering based on 2nup.

Available structures: 2nup, 2nut

Identifiers

Symbol(s)

SEC23A; CLSD; MGC26267

External IDs

OMIM: 610511 MGI: 1349635 HomoloGene: 4642

Gene ontology
Molecular Function:	• protein binding • zinc ion binding
Cellular Component:	• Golgi membrane • endoplasmic reticulum • cytosol • COPII vesicle coat • perinuclear region of cytoplasm
Biological Process:	• intracellular protein transport • ER to Golgi vesicle-mediated transport • vesicle-mediated transport

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_006364 (mRNA)
NP_006355 (protein)

NM_009147 (mRNA)
NP_033173 (protein)

Location

Chr 14: 38.57 - 38.64 Mb

Chr 12: 59.88 - 59.93 Mb

Pubmed search

[1]

[2]

Sec23 homolog A (S. cerevisiae), also known as SEC23A, is a human gene.^[1]

The protein encoded by this gene is a member of the SEC23 subfamily of the SEC23/SEC24 family. It is part of a protein complex and found in the ribosome-free transitional face of the endoplasmic reticulum (ER) and associated vesicles. This protein has similarity to yeast Sec23p component of COPII. COPII is the coat protein complex responsible for vesicle budding from the ER. The encoded protein is suggested to play a role in the ER-Golgi protein trafficking.^[1]

[edit] References

^ ^a ^b Entrez Gene: SEC23A Sec23 homolog A (S. cerevisiae).

[edit] Further reading

Paccaud JP, Reith W, Carpentier JL, et al. (1997). "Cloning and functional characterization of mammalian homologues of the COPII component Sec23.". Mol. Biol. Cell 7 (10): 1535–46. PMID 8898360.
Pagano A, Letourneur F, Garcia-Estefania D, et al. (1999). "Sec24 proteins and sorting at the endoplasmic reticulum.". J. Biol. Chem. 274 (12): 7833–40. PMID 10075675.
Tang BL, Kausalya J, Low DY, et al. (1999). "A family of mammalian proteins homologous to yeast Sec24p.". Biochem. Biophys. Res. Commun. 258 (3): 679–84. doi:10.1006/bbrc.1999.0574. PMID 10329445.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Heilig R, Eckenberg R, Petit JL, et al. (2003). "The DNA sequence and analysis of human chromosome 14.". Nature 421 (6923): 601–7. doi:10.1038/nature01348. PMID 12508121.
Boyadjiev SA, Justice CM, Eyaid W, et al. (2003). "A novel dysmorphic syndrome with open calvarial sutures and sutural cataracts maps to chromosome 14q13-q21.". Hum. Genet. 113 (1): 1–9. doi:10.1007/s00439-003-0932-6. PMID 12677423.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Dudognon P, Maeder-Garavaglia C, Carpentier JL, Paccaud JP (2004). "Regulation of a COPII component by cytosolic O-glycosylation during mitosis.". FEBS Lett. 561 (1-3): 44–50. doi:10.1016/S0014-5793(04)00109-7. PMID 15013749.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Watson P, Forster R, Palmer KJ, et al. (2005). "Coupling of ER exit to microtubules through direct interaction of COPII with dynactin.". Nat. Cell Biol. 7 (1): 48–55. doi:10.1038/ncb1206. PMID 15580264.
Palmer KJ, Konkel JE, Stephens DJ (2005). "PCTAIRE protein kinases interact directly with the COPII complex and modulate secretory cargo transport.". J. Cell. Sci. 118 (Pt 17): 3839–47. doi:10.1242/jcs.02496. PMID 16091426.
Boyadjiev SA, Fromme JC, Ben J, et al. (2006). "Cranio-lenticulo-sutural dysplasia is caused by a SEC23A mutation leading to abnormal endoplasmic-reticulum-to-Golgi trafficking.". Nat. Genet. 38 (10): 1192–7. doi:10.1038/ng1876. PMID 16980979.
Tu LC, Yan X, Hood L, Lin B (2007). "Proteomics analysis of the interactome of N-myc downstream regulated gene 1 and its interactions with the androgen response program in prostate cancer cells.". Mol. Cell Proteomics 6 (4): 575–88. doi:10.1074/mcp.M600249-MCP200. PMID 17220478.