SCYL1

From Wikipedia, the free encyclopedia

SCY1-like 1 (S. cerevisiae)

Identifiers

SCYL1; TRAP; GKLP; HT019; MGC78454; NKTL; NTKL; P105; TAPK; TEIF

External IDs

OMIM: 607982 MGI: 1931787 HomoloGene: 6947

Gene ontology
Molecular Function:	• DNA binding • protein-tyrosine kinase activity • protein binding • ATP binding
Cellular Component:	• nucleus • cytoplasm
Biological Process:	• transcription • regulation of transcription, DNA-dependent • protein amino acid phosphorylation • biological_process

Orthologs

Human

Mouse

Refseq

NM_001048218 (mRNA)
NP_001041683 (protein)

NM_023912 (mRNA)
NP_076401 (protein)

Location

Chr 11: 65.05 - 65.06 Mb

Chr 19: 5.76 - 5.77 Mb

Pubmed search

[1]

[2]

SCY1-like 1 (S. cerevisiae), also known as SCYL1, is a human gene.^[1]

This gene encodes a transcriptional regulator belonging to the SCY1-like family of kinase-like proteins. The protein has a divergent N-terminal kinase domain that is thought to be catalytically inactive, and can bind specific DNA sequences through its C-terminal domain. It activates transcription of the telomerase reverse transcriptase and DNA polymerase beta genes. The protein has been localized to the nucleus, and also to the cytoplasm and centrosomes during mitosis. Multiple transcript variants encoding different isoforms have been found for this gene.^[1]

[edit] References

^ ^a ^b Entrez Gene: SCYL1 SCY1-like 1 (S. cerevisiae).

[edit] Further reading

Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. PMID 8889548.
van Asseldonk M, Schepens M, de Bruijn D, et al. (2000). "Construction of a 350-kb sequence-ready 11q13 cosmid contig encompassing the markers D11S4933 and D11S546: mapping of 11 genes and 3 tumor-associated translocation breakpoints.". Genomics 66 (1): 35–42. doi:10.1006/geno.2000.6194. PMID 10843802.
Carninci P, Shibata Y, Hayatsu N, et al. (2001). "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.". Genome Res. 10 (10): 1617–30. PMID 11042159.
Liu SC, Lane WS, Lienhard GE (2001). "Cloning and preliminary characterization of a 105 kDa protein with an N-terminal kinase-like domain.". Biochim. Biophys. Acta 1517 (1): 148–52. PMID 11118629.
Kato M, Yano K, Morotomi-Yano K, et al. (2002). "Identification and characterization of the human protein kinase-like gene NTKL: mitosis-specific centrosomal localization of an alternatively spliced isoform.". Genomics 79 (6): 760–7. doi:10.1006/geno.2002.6774. PMID 12036289.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Di Y, Li J, Fang J, et al. (2004). "Cloning and characterization of a novel gene which encodes a protein interacting with the mitosis-associated kinase-like protein NTKL.". J. Hum. Genet. 48 (6): 315–21. doi:10.1007/s10038-003-0031-5. PMID 12783284.
Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMID 15342556.
Bohlson SS, Zhang M, Ortiz CE, Tenner AJ (2005). "CD93 interacts with the PDZ domain-containing adaptor protein GIPC: implications in the modulation of phagocytosis.". J. Leukoc. Biol. 77 (1): 80–9. doi:10.1189/jlb.0504305. PMID 15459234.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Tang Z, Zhao Y, Mei F, et al. (2005). "Molecular cloning and characterization of a human gene involved in transcriptional regulation of hTERT.". Biochem. Biophys. Res. Commun. 324 (4): 1324–32. doi:10.1016/j.bbrc.2004.09.201. PMID 15504359.
Zhao Y, Zheng J, Ling Y, et al. (2005). "Transcriptional upregulation of DNA polymerase beta by TEIF.". Biochem. Biophys. Res. Commun. 333 (3): 908–16. doi:10.1016/j.bbrc.2005.05.172. PMID 15963946.
Mei F, Zhang B, Tang ZW, Hou L (2006). "Expression of a telomerase-associated gene in normal, atrophic, and tumorous testes.". Chin. Med. Sci. J. 20 (3): 217–20. PMID 16261899.
Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.". Cell 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
Schmid EM, Ford MG, Burtey A, et al. (2007). "Role of the AP2 beta-appendage hub in recruiting partners for clathrin-coated vesicle assembly.". PLoS Biol. 4 (9): e262. doi:10.1371/journal.pbio.0040262. PMID 16903783.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.