SCYE1

From Wikipedia, the free encyclopedia

Small inducible cytokine subfamily E, member 1 (endothelial monocyte-activating)

PDB rendering based on 1e7z.

Available structures: 1e7z, 1euj, 1fl0

Identifiers

Symbol(s)

SCYE1; AIMP1; EMAP II; EMAP-2; EMAP-II; EMAP2; EMAPII; p43

External IDs

OMIM: 603605 MGI: 102774 HomoloGene: 31260

Gene ontology
Molecular Function:	• tRNA binding • cytokine activity
Cellular Component:	• extracellular space
Biological Process:	• tRNA aminoacylation for protein translation • chemotaxis • inflammatory response • signal transduction • cell-cell signaling

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_004757 (mRNA)
NP_004748 (protein)

NM_007926 (mRNA)
NP_031952 (protein)

Location

Chr 4: 107.46 - 107.49 Mb

n/a

Pubmed search

[1]

[2]

Small inducible cytokine subfamily E, member 1 (endothelial monocyte-activating), also known as SCYE1, is a human gene.^[1]

The protein encoded by this gene is a cytokine that is specifically induced by apoptosis. The release of this cytokine renders the tumor-associated vasculature sensitive to tumor necrosis factor. The precursor of SCYE1 (pro-SCYE1) is identical to the p43 subunit, which is associated with the multi-tRNA synthetase complex. Therefore, pro-SCYE1 may function in binding RNA as part of the tRNA synthetase complex in normal cells and in stimulating inflammatory responses after proteolytic cleavage in tumor cells.^[1]

[edit] References

^ ^a ^b Entrez Gene: SCYE1 small inducible cytokine subfamily E, member 1 (endothelial monocyte-activating).

[edit] Further reading

Kao J, Ryan J, Brett G, et al. (1992). "Endothelial monocyte-activating polypeptide II. A novel tumor-derived polypeptide that activates host-response mechanisms.". J. Biol. Chem. 267 (28): 20239-47. PMID 1400342.
Kao J, Fan YG, Haehnel I, et al. (1994). "A peptide derived from the amino terminus of endothelial-monocyte-activating polypeptide II modulates mononuclear and polymorphonuclear leukocyte functions, defines an apparently novel cellular interaction site, and induces an acute inflammatory response.". J. Biol. Chem. 269 (13): 9774-82. PMID 7545917.
Kao J, Houck K, Fan Y, et al. (1994). "Characterization of a novel tumor-derived cytokine. Endothelial-monocyte activating polypeptide II.". J. Biol. Chem. 269 (40): 25106-19. PMID 7929199.
Quevillon S, Agou F, Robinson JC, Mirande M (1998). "The p43 component of the mammalian multi-synthetase complex is likely to be the precursor of the endothelial monocyte-activating polypeptide II cytokine.". J. Biol. Chem. 272 (51): 32573-9. PMID 9405472.
Quevillon S, Robinson JC, Berthonneau E, et al. (1999). "Macromolecular assemblage of aminoacyl-tRNA synthetases: identification of protein-protein interactions and characterization of a core protein.". J. Mol. Biol. 285 (1): 183-95. doi:10.1006/jmbi.1998.2316. PMID 9878398.
Park SG, Jung KH, Lee JS, et al. (1999). "Precursor of pro-apoptotic cytokine modulates aminoacylation activity of tRNA synthetase.". J. Biol. Chem. 274 (24): 16673-6. PMID 10358004.
Kim Y, Shin J, Li R, et al. (2000). "A novel anti-tumor cytokine contains an RNA binding motif present in aminoacyl-tRNA synthetases.". J. Biol. Chem. 275 (35): 27062-8. doi:10.1074/jbc.C000216200. PMID 10852899.
Renault L, Kerjan P, Pasqualato S, et al. (2001). "Structure of the EMAPII domain of human aminoacyl-tRNA synthetase complex reveals evolutionary dimer mimicry.". EMBO J. 20 (3): 570-8. doi:10.1093/emboj/20.3.570. PMID 11157763.
Shalak V, Kaminska M, Mitnacht-Kraus R, et al. (2001). "The EMAPII cytokine is released from the mammalian multisynthetase complex after cleavage of its p43/proEMAPII component.". J. Biol. Chem. 276 (26): 23769-76. doi:10.1074/jbc.M100489200. PMID 11306575.
Chang SY, Park SG, Kim S, Kang CY (2002). "Interaction of the C-terminal domain of p43 and the alpha subunit of ATP synthase. Its functional implication in endothelial cell proliferation.". J. Biol. Chem. 277 (10): 8388-94. doi:10.1074/jbc.M108792200. PMID 11741979.
Battersby S, Boddy SC, Critchley HO, Jabbour HN (2002). "Expression and localization of endothelial monocyte-activating polypeptide II in the human endometrium across the menstrual cycle: regulation of expression by prostaglandin E(2).". J. Clin. Endocrinol. Metab. 87 (8): 3928-35. PMID 12161535.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Park H, Park SG, Kim J, et al. (2003). "Signaling pathways for TNF production induced by human aminoacyl-tRNA synthetase-associating factor, p43.". Cytokine 20 (4): 148-53. PMID 12543078.
Ahn HC, Kim S, Lee BJ (2003). "Solution structure and p43 binding of the p38 leucine zipper motif: coiled-coil interactions mediate the association between p38 and p43.". FEBS Lett. 542 (1-3): 119-24. PMID 12729910.
Kim MJ, Park BJ, Kang YS, et al. (2003). "Downregulation of FUSE-binding protein and c-myc by tRNA synthetase cofactor p38 is required for lung cell differentiation.". Nat. Genet. 34 (3): 330-6. doi:10.1038/ng1182. PMID 12819782.
Wolfe CL, Warrington JA, Davis S, et al. (2004). "Isolation and characterization of human nuclear and cytosolic multisynthetase complexes and the intracellular distribution of p43/EMAPII.". Protein Sci. 12 (10): 2282-90. PMID 14500886.
Mueller CA, Schluesener HJ, Conrad S, et al. (2004). "Spinal cord injury induces lesional expression of the proinflammatory and antiangiogenic cytokine EMAP II.". J. Neurotrauma 20 (10): 1007-15. doi:10.1089/089771503770195858. PMID 14588117.
Murray JC, Symonds P, Ward W, et al. (2004). "Colorectal cancer cells induce lymphocyte apoptosis by an endothelial monocyte-activating polypeptide-II-dependent mechanism.". J. Immunol. 172 (1): 274-81. PMID 14688335.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Murray JC, Heng YM, Symonds P, et al. (2004). "Endothelial monocyte-activating polypeptide-II (EMAP-II): a novel inducer of lymphocyte apoptosis.". J. Leukoc. Biol. 75 (5): 772-6. doi:10.1189/jlb.1003487. PMID 14982944.