SCRIB

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Scribbled homolog (Drosophila)
PDB rendering based on 1uju.
Available structures: 1uju, 1wha, 1x5q
Identifiers
Symbol(s) SCRIB; CRIB1; SCRB1; SCRIB1; Vartul
External IDs OMIM: 607733 MGI: 2145950 HomoloGene: 44228
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 23513 105782
Ensembl ENSG00000180900 ENSMUSG00000022568
Uniprot Q14160 Q6P9N3
Refseq NM_015356 (mRNA)
NP_056171 (protein)		 NM_134089 (mRNA)
NP_598850 (protein)
Location Chr 8: 144.95 - 144.97 Mb Chr 15: 75.87 - 75.9 Mb
Pubmed search [1] [2]

Scribbled homolog (Drosophila), also known as SCRIB, is a human gene.[1]


[edit] References

  1. ^ Entrez Gene: SCRIB scribbled homolog (Drosophila).

[edit] Further reading

  • Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.". DNA Res. 9 (3): 99-106. PMID 12168954. 
  • Nagase T, Seki N, Tanaka A, et al. (1996). "Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1.". DNA Res. 2 (4): 167-74, 199-210. PMID 8590280. 
  • Nakagawa S, Huibregtse JM (2000). "Human scribble (Vartul) is targeted for ubiquitin-mediated degradation by the high-risk papillomavirus E6 proteins and the E6AP ubiquitin-protein ligase.". Mol. Cell. Biol. 20 (21): 8244-53. PMID 11027293. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Dow LE, Brumby AM, Muratore R, et al. (2004). "hScrib is a functional homologue of the Drosophila tumour suppressor Scribble.". Oncogene 22 (58): 9225-30. doi:10.1038/sj.onc.1207154. PMID 14681682. 
  • Nakagawa S, Yano T, Nakagawa K, et al. (2004). "Analysis of the expression and localisation of a LAP protein, human scribble, in the normal and neoplastic epithelium of uterine cervix.". Br. J. Cancer 90 (1): 194-9. doi:10.1038/sj.bjc.6601465. PMID 14710229. 
  • Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway.". Nat. Cell Biol. 6 (2): 97-105. doi:10.1038/ncb1086. PMID 14743216. 
  • Brill LM, Salomon AR, Ficarro SB, et al. (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.". Anal. Chem. 76 (10): 2763-72. doi:10.1021/ac035352d. PMID 15144186. 
  • Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation.". Genome Res. 14 (7): 1315-23. doi:10.1101/gr.2122004. PMID 15231747. 
  • Borg JP (2004). "[hScrib: a potential novel tumor suppressor]". Pathol. Biol. 52 (6): 328-31. doi:10.1016/j.patbio.2003.09.015. PMID 15261375. 
  • Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130-5. doi:10.1073/pnas.0404720101. PMID 15302935. 
  • Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain.". Mol. Cell Proteomics 3 (11): 1093-101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Petit MM, Meulemans SM, Alen P, et al. (2006). "The tumor suppressor Scrib interacts with the zyxin-related protein LPP, which shuttles between cell adhesion sites and the nucleus.". BMC Cell Biol. 6 (1): 1. doi:10.1186/1471-2121-6-1. PMID 15649318. 
  • Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells.". Science 307 (5715): 1621-5. doi:10.1126/science.1105776. PMID 15761153. 
  • Lahuna O, Quellari M, Achard C, et al. (2005). "Thyrotropin receptor trafficking relies on the hScrib-betaPIX-GIT1-ARF6 pathway.". EMBO J. 24 (7): 1364-74. doi:10.1038/sj.emboj.7600616. PMID 15775968. 
  • Navarro C, Nola S, Audebert S, et al. (2005). "Junctional recruitment of mammalian Scribble relies on E-cadherin engagement.". Oncogene 24 (27): 4330-9. doi:10.1038/sj.onc.1208632. PMID 15806148. 
  • Métais JY, Navarro C, Santoni MJ, et al. (2005). "hScrib interacts with ZO-2 at the cell-cell junctions of epithelial cells.". FEBS Lett. 579 (17): 3725-30. doi:10.1016/j.febslet.2005.05.062. PMID 15975580. 
  • Thomas M, Massimi P, Navarro C, et al. (2005). "The hScrib/Dlg apico-basal control complex is differentially targeted by HPV-16 and HPV-18 E6 proteins.". Oncogene 24 (41): 6222-30. doi:10.1038/sj.onc.1208757. PMID 16103886. 
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