SCMH1

From Wikipedia, the free encyclopedia

Sex comb on midleg homolog 1 (Drosophila)

PDB rendering based on 2p0k.

Available structures: 2p0k

Identifiers

Symbol(s)

SCMH1; Scml3

External IDs

MGI: 1352762 HomoloGene: 32146

Gene ontology
Molecular Function:	• transcription factor activity • protein binding • transcription repressor activity
Cellular Component:	• nucleus
Biological Process:	• regulation of transcription, DNA-dependent • multicellular organismal development • anatomical structure morphogenesis • gene silencing • negative regulation of transcription

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001031694 (mRNA)
NP_001026864 (protein)

NM_013883 (mRNA)
NP_038911 (protein)

Location

Chr 1: 41.27 - 41.48 Mb

Chr 4: 119.95 - 120.03 Mb

Pubmed search

[1]

[2]

Sex comb on midleg homolog 1 (Drosophila), also known as SCMH1, is a human gene.^[1]

[edit] References

^ Entrez Gene: SCMH1 sex comb on midleg homolog 1 (Drosophila).

[edit] Further reading

Berger J, Kurahashi H, Takihara Y, et al. (1999). "The human homolog of Sex comb on midleg (SCMH1) maps to chromosome 1p34.". Gene 237 (1): 185–91. PMID 10524249.
Tomotsune D, Takihara Y, Berger J, et al. (2000). "A novel member of murine Polycomb-group proteins, Sex comb on midleg homolog protein, is highly conserved, and interacts with RAE28/mph1 in vitro.". Differentiation 65 (4): 229–39. PMID 10653359.
Levine SS, Weiss A, Erdjument-Bromage H, et al. (2002). "The core of the polycomb repressive complex is compositionally and functionally conserved in flies and humans.". Mol. Cell. Biol. 22 (17): 6070–8. PMID 12167701.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Luo L, Yang X, Takihara Y, et al. (2004). "The cell-cycle regulator geminin inhibits Hox function through direct and polycomb-mediated interactions.". Nature 427 (6976): 749–53. doi:10.1038/nature02305. PMID 14973489.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome.". Cell 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.". Cell 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.