Schiller-Duval body

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A Schiller-Duval body is a cellular structure seen by microscope in endodermal sinus tumors. Schiller-Duval bodies are present in approximately 50% of these tumors, and if found are pathognomonic. [1] They are named for Mathias-Marie Duval and Walter Schiller [2] who described them in the late nineteenth century. [3][4]

Schiller-Duval bodies are said to resemble a glomerulus.[5] They have a mesodermal core with a central capillary, all lined by flattened layers of both visceral and parietal cells. Immunofluorescent stain may show eosinophilic hyalin-like globules both inside and outside the cytoplasm that contain AFP and alpha 1-antitrypsin.

[edit] References

  1. ^ Kumar, Abbas, Fausto. Pathologic Basis of Disease, 7th edition. Philadelphia; Elsevier-Saunders, 2005. 1042.
  2. ^ "Schiller-Duval bodies" at whonamedit.com [1]
  3. ^ Duval M. Le placenta des rongeurs. Journal de l'anatomie et de la physiologie normales et pathologiques de l'homme et des animaux, Paris, 1891, 27: 24–73, 344–395, 513–612.
  4. ^ Duval M. Le placenta des rongeurs. Paris, Felix Alcan, 1892.
  5. ^ Kumar, Abbas, Fausto. Pathologic Basis of Disease, 7th edition. Philadelphia; Elsevier-Saunders, 2005. 1101.
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