SCGN

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Secretagogin, EF-hand calcium binding protein
Identifiers
Symbol(s) SCGN; CALBL; DJ501N12.8; SECRET; SEGN; setagin
External IDs OMIM: 609202 MGI: 2384873 HomoloGene: 5088
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 10590 214189
Ensembl ENSG00000079689 ENSMUSG00000021337
Uniprot O76038 Q5NCL7
Refseq NM_006998 (mRNA)
NP_008929 (protein)		 NM_145399 (mRNA)
NP_663374 (protein)
Location Chr 6: 25.76 - 25.81 Mb Chr 13: 23.96 - 24 Mb
Pubmed search [1] [2]

Secretagogin, EF-hand calcium binding protein, also known as SCGN, is a human gene.[1]

The encoded protein is a secreted calcium-binding protein which is found in the cytoplasm. It is related to calbindin D-28K and calretinin. This protein is thought to be involved in KCL-stimulated calcium flux and cell proliferation.[1]

[edit] References

  1. ^ a b Entrez Gene: SCGN secretagogin, EF-hand calcium binding protein.

[edit] Further reading

  • Wagner L, Oliyarnyk O, Gartner W, et al. (2000). "Cloning and expression of secretagogin, a novel neuroendocrine- and pancreatic islet of Langerhans-specific Ca2+-binding protein.". J. Biol. Chem. 275 (32): 24740-51. doi:10.1074/jbc.M001974200. PMID 10811645. 
  • Gartner W, Lang W, Leutmetzer F, et al. (2002). "Cerebral expression and serum detectability of secretagogin, a recently cloned EF-hand Ca(2+)-binding protein.". Cereb. Cortex 11 (12): 1161-9. PMID 11709487. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805-11. doi:10.1038/nature02055. PMID 14574404. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039. 
  • Zhan X, Evans CO, Oyesiku NM, Desiderio DM (2004). "Proteomics and transcriptomics analyses of secretagogin down-regulation in human non-functional pituitary adenomas.". Pituitary 6 (4): 189-202. PMID 15237930. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Zierhut B, Daneva T, Gartner W, et al. (2005). "Setagin and secretagogin-R22: Posttranscriptional modification products of the secretagogin gene.". Biochem. Biophys. Res. Commun. 329 (4): 1193-9. doi:10.1016/j.bbrc.2005.02.093. PMID 15766553. 
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514. 
  • Skovhus KV, Bergholdt R, Erichsen C, et al. (2007). "Identification and characterization of secretagogin promoter activity.". Scand. J. Immunol. 64 (6): 639-45. doi:10.1111/j.1365-3083.2006.01854.x. PMID 17083620. 
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