SCG5

From Wikipedia, the free encyclopedia

Secretogranin V (7B2 protein)

Identifiers

SCG5; 7B2; P7B2; SGNE1; SgV

External IDs

OMIM: 173120 MGI: 98289 HomoloGene: 37722

Gene ontology
Molecular Function:	• enzyme inhibitor activity • GTP binding • enzyme activator activity • unfolded protein binding
Cellular Component:	• secretory granule
Biological Process:	• protein folding • transport • intracellular protein transport • neuropeptide signaling pathway • peptide hormone processing • regulation of hormone secretion

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_003020 (mRNA)
NP_003011 (protein)

NM_009162 (mRNA)
NP_033188 (protein)

Location

Chr 15: 30.72 - 30.78 Mb

Chr 2: 113.58 - 113.63 Mb

Pubmed search

[1]

[2]

Secretogranin V (7B2 protein), also known as SCG5, is a human gene.^[1]

[edit] References

^ Entrez Gene: SCG5 secretogranin V (7B2 protein).

[edit] Further reading

Mbikay M, Seidah NG, Chrétien M (2001). "Neuroendocrine secretory protein 7B2: structure, expression and functions.". Biochem. J. 357 (Pt 2): 329–42. PMID 11439082.
Taupenot L, Harper KL, O'Connor DT (2003). "The chromogranin-secretogranin family.". N. Engl. J. Med. 348 (12): 1134–49. doi:10.1056/NEJMra021405. PMID 12646671.
Paquet L, Lazure C, Seidah NG, et al. (1991). "The production by alternate splicing of two mRNAs differing by one codon could be an intrinsic property of neuroendocrine protein 7B2 gene expression in man.". Biochem. Biophys. Res. Commun. 174 (1): 156–62. PMID 1989596.
Roebroek AJ, Dehaen MR, van Bokhoven A, et al. (1989). "Regional mapping of the human gene encoding the novel pituitary polypeptide 7B2 to chromosome 15q13----q14 by in situ hybridization.". Cytogenet. Cell Genet. 50 (2-3): 158–60. PMID 2776483.
Benjannet S, Marcinkiewicz M, Falgueyret JP, et al. (1988). "Secretory protein 7B2 is associated with pancreatic hormones within normal islets and some experimentally induced tumors.". Endocrinology 123 (2): 874–84. PMID 2840270.
Martens GJ (1988). "Cloning and sequence analysis of human pituitary cDNA encoding the novel polypeptide 7B2.". FEBS Lett. 234 (1): 160–4. PMID 3134253.
Brayton KA, Aimi J, Qiu H, et al. (1989). "Cloning, characterization, and sequence of a porcine cDNA encoding a secreted neuronal and endocrine protein.". DNA 7 (10): 713–9. PMID 3234177.
Marcinkiewicz M, Benjannet S, Falgueyret JP, et al. (1988). "Identification and localization of 7B2 protein in human, porcine, and rat thyroid gland and in human medullary carcinoma.". Endocrinology 123 (2): 866–73. PMID 3293987.
Marcinkiewicz M, Benjannet S, Cantin M, et al. (1986). "CNS distribution of a novel pituitary protein '7B2': localization in secretory and synaptic vesicles.". Brain Res. 380 (2): 349–56. PMID 3530373.
Seidah NG, Hsi KL, De Serres G, et al. (1983). "Isolation and NH2-terminal sequence of a highly conserved human and porcine pituitary protein belonging to a new superfamily. Immunocytochemical localization in pars distalis and pars nervosa of the pituitary and in the supraoptic nucleus of the hypothalamus.". Arch. Biochem. Biophys. 225 (2): 525–34. PMID 6625600.
Benjannet S, Savaria D, Chrétien M, Seidah NG (1995). "7B2 is a specific intracellular binding protein of the prohormone convertase PC2.". J. Neurochem. 64 (5): 2303–11. PMID 7722516.
Braks JA, Martens GJ (1994). "7B2 is a neuroendocrine chaperone that transiently interacts with prohormone convertase PC2 in the secretory pathway.". Cell 78 (2): 263–73. PMID 7913882.
Lloyd RV, Jin L (1994). "Analysis of chromogranin/secretogranin messenger RNAs in human pituitary adenomas.". Diagn. Mol. Pathol. 3 (1): 38–45. PMID 8162254.
Braks JA, Broers CA, Danger JM, Martens GJ (1996). "Structural organization of the gene encoding the neuroendocrine chaperone 7B2.". Eur. J. Biochem. 236 (1): 60–7. PMID 8617287.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Bourdeau I, Antonini SR, Lacroix A, et al. (2004). "Gene array analysis of macronodular adrenal hyperplasia confirms clinical heterogeneity and identifies several candidate genes as molecular mediators.". Oncogene 23 (8): 1575–85. doi:10.1038/sj.onc.1207277. PMID 14767469.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.". Cell 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.