SCAND1

From Wikipedia, the free encyclopedia

SCAN domain containing 1

Identifiers

SCAND1; RAZ1; SDP1

External IDs

OMIM: 610416 MGI: 1343132 HomoloGene: 10642

Gene ontology
Molecular Function:	• transcription factor activity • RNA binding • transcription factor binding • identical protein binding
Cellular Component:	• nucleus
Biological Process:	• regulation of progression through cell cycle • regulation of transcription, DNA-dependent • regulation of cell proliferation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_016558 (mRNA)
NP_057642 (protein)

NM_020255 (mRNA)
NP_064651 (protein)

Location

Chr 20: 34 - 34.01 Mb

n/a

Pubmed search

[1]

[2]

SCAN domain containing 1, also known as SCAND1, is a human gene.^[1]

The SCAN domain is a highly conserved, leucine-rich motif of approximately 60 aa originally found within a subfamily of zinc finger proteins. This gene belongs to a family of genes that encode an isolated SCAN domain, but no zinc finger motif. Functional studies have established that the SCAN box is a protein interaction domain that mediates both hetero- and homoprotein associations, and maybe involved in regulation of transcriptional activity. Two transcript variants with different 5' UTRs, but encoding the same protein, have been described for this gene.^[1]

[edit] References

^ ^a ^b Entrez Gene: SCAND1 SCAN domain containing 1.

[edit] Further reading

Williams AJ, Blacklow SC, Collins T (2000). "The zinc finger-associated SCAN box is a conserved oligomerization domain.". Mol. Cell. Biol. 19 (12): 8526–35. PMID 10567577.
Schumacher C, Wang H, Honer C, et al. (2000). "The SCAN domain mediates selective oligomerization.". J. Biol. Chem. 275 (22): 17173–9. doi:10.1074/jbc.M000119200. PMID 10747874.
Sander TL, Haas AL, Peterson MJ, Morris JF (2000). "Identification of a novel SCAN box-related protein that interacts with MZF1B. The leucine-rich SCAN box mediates hetero- and homoprotein associations.". J. Biol. Chem. 275 (17): 12857–67. PMID 10777584.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. PMID 11076863.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
Sander TL, Morris JF (2003). "Characterization of the SCAN box encoding RAZ1 gene: analysis of cDNA transcripts, expression, and cellular localization.". Gene 296 (1-2): 53–64. PMID 12383503.
Babb R, Bowen BR (2003). "SDP1 is a peroxisome-proliferator-activated receptor gamma 2 co-activator that binds through its SCAN domain.". Biochem. J. 370 (Pt 2): 719–27. doi:10.1042/BJ20021378. PMID 12444922.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMID 15489336.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMID 16381901.
Carneiro FR, Silva TC, Alves AC, et al. (2006). "Spectroscopic characterization of the tumor antigen NY-REN-21 and identification of heterodimer formation with SCAND1.". Biochem. Biophys. Res. Commun. 343 (1): 260–8. doi:10.1016/j.bbrc.2006.02.140. PMID 16540086.