Talk:Sativex

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From the article: "Sativex Is basically a Liquid form of Marijuana with one exception, it cannot get you high"

Is this true? I would imagine that the only difference from marijuana is the delivery method, i.e., smoked vs. mucous membrane absorption/ingestion; if the THC and cannibidiol weren't affecting the central nervous system, how would they relieve pain?. Can anyone verify this? It seems a rather unsubstantiated and unscientific claim, but I'll leave it alone til some perspective is gained.

I removed this unsupported assertion. If taken in sufficient amounts, Sativex will produce a high similar to smoking a spliff. JFW | T@lk 21:55, 29 September 2005 (UTC)
Not only that, but the instructions for the medication -specifically- state that 'intoxication' is a common side effect, especially when starting off. They also say that if intoxication occurs, one should taper back usage of the medication until it no longer is a problem. - Pacula 14:04, 10 May 2007 (UTC)

[edit] Incorrect information

"(Sativex will remain a Schedule 1 controlled drug in the UK)"

The UK doesn't use the Schedule system that America does. It uses a system of drug classes (Class A, B, C). Do they mean it's Class C (the same as cannabis atm) or what? Haddock420 01:43, 26 December 2005 (UTC)

That came straight from the GW Pharmaceuticals press release dated 2005/11/15. Anarchist42 23:23, 26 December 2005 (UTC)

The UK uses classes and schedules - for example Anabolic Steroids are Class C, Schedule III, I believe, which means that they are illegal without prescription but do have medicinal purposes. Cannabis medications would therefore most likely be in this class and will remain illegal without prescription.

[1]

[edit] A woman suffered a fatality

Lucky she didn't die. The Real Walrus 23:08, 1 June 2006 (UTC)

Re above: You can not suffer a fatality and not die, thats contradiction in terms. Does any one know the LD50 of THC and CBN? 08:36, 29 August 2007 (UTC)~

From the Merck Index, 12th edition. 9349. The LD50 was measured in rats at 1270mg/kg (males) and 730mg/kg(females) given as an oral suspension in oil. It was 40mg/kg in male and female rats by IV. The value for inhalation in rats (corrected for particulate losses etc) was 42mg/kg. The values are reported for the Δ9-THC isomer. Jeff Dahl 22:36, 3 September 2007 (UTC)

[edit] This paragraph

This paragraph reads like an advertisement or promotional material from the company (bold text added to point out what I see as unencyclopedic, non-neutral text)

'"In February 2007, GW and Otsuka Pharmaceutical announced an exclusive agreement for Otsuka to develop and market Sativex in the United States. Otsuka is a major global pharmaceutical company, best known for its antipsychotic blockbuster medication, Abilify. Sativex has received permission from the US regulatory authority, the FDA, to enter directly into late stage Phase III trials in the US. The first large scale US trial in the US for cancer patients is expected to start in summer 2007. The 300-patient, double-blind, randomized, placebo-controlled study will evaluate the effect of Sativex in relieving average daily pain, reducing the use of breakthrough opioid medications, improving the quality of sleep and relevant aspects of quality of life among other outcome measures."'

Particularly the last part: it seems predictive rather than narrative. Also "expected to start in summer 2007" -- it is now 2008, so wherever this came from (no citation either) it needs to be updated. I don't have the resources to correct this paragraph without damaging the good parts. User:Pedant (talk) 07:57, 5 January 2008 (UTC)

Also the word 'blockbuster' is inappropriate. Mjpresson (talk) 00:59, 1 February 2008 (UTC)