SAE2

From Wikipedia, the free encyclopedia

SUMO1 activating enzyme subunit 2

PDB rendering based on 1y8q.

Available structures: 1y8q, 1y8r

Identifiers

Symbol(s)

SAE2; FLJ13058; HRIHFB2115; UBA2

External IDs

MGI: 1858313 HomoloGene: 4018

Gene ontology
Molecular Function:	• nucleotide binding • ubiquitin activating enzyme activity • ATP binding • enzyme activator activity • ligase activity
Cellular Component:	• nucleus
Biological Process:	• ubiquitin cycle

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_005499 (mRNA)
NP_005490 (protein)

NM_016682 (mRNA)
NP_057891 (protein)

Location

Chr 19: 39.61 - 39.65 Mb

Chr 7: 33.85 - 33.88 Mb

Pubmed search

[1]

[2]

SUMO1 activating enzyme subunit 2, also known as SAE2, is a human gene.^[1]

[edit] References

^ Entrez Gene: SAE2 SUMO1 activating enzyme subunit 2.

[edit] Further reading

Ueki N, Oda T, Kondo M, et al. (1999). "Selection system for genes encoding nuclear-targeted proteins.". Nat. Biotechnol. 16 (13): 1338–42. doi:10.1038/4315. PMID 9853615.
Okuma T, Honda R, Ichikawa G, et al. (1999). "In vitro SUMO-1 modification requires two enzymatic steps, E1 and E2.". Biochem. Biophys. Res. Commun. 254 (3): 693–8. doi:10.1006/bbrc.1998.9995. PMID 9920803.
Desterro JM, Rodriguez MS, Kemp GD, Hay RT (1999). "Identification of the enzyme required for activation of the small ubiquitin-like protein SUMO-1.". J. Biol. Chem. 274 (15): 10618–24. PMID 10187858.
Gong L, Li B, Millas S, Yeh ET (1999). "Molecular cloning and characterization of human AOS1 and UBA2, components of the sentrin-activating enzyme complex.". FEBS Lett. 448 (1): 185–9. PMID 10217437.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. doi:10.1101/gr.154701. PMID 11230166.
Tatham MH, Jaffray E, Vaughan OA, et al. (2001). "Polymeric chains of SUMO-2 and SUMO-3 are conjugated to protein substrates by SAE1/SAE2 and Ubc9.". J. Biol. Chem. 276 (38): 35368–74. doi:10.1074/jbc.M104214200. PMID 11451954.
Azuma Y, Tan SH, Cavenagh MM, et al. (2001). "Expression and regulation of the mammalian SUMO-1 E1 enzyme.". FASEB J. 15 (10): 1825–7. PMID 11481243.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Tatham MH, Kim S, Yu B, et al. (2003). "Role of an N-terminal site of Ubc9 in SUMO-1, -2, and -3 binding and conjugation.". Biochemistry 42 (33): 9959–69. doi:10.1021/bi0345283. PMID 12924945.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Boggio R, Colombo R, Hay RT, et al. (2005). "A mechanism for inhibiting the SUMO pathway.". Mol. Cell 16 (4): 549–61. doi:10.1016/j.molcel.2004.11.007. PMID 15546615.
Lois LM, Lima CD (2005). "Structures of the SUMO E1 provide mechanistic insights into SUMO activation and E2 recruitment to E1.". EMBO J. 24 (3): 439–51. doi:10.1038/sj.emboj.7600552. PMID 15660128.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Bossis G, Melchior F (2006). "Regulation of SUMOylation by reversible oxidation of SUMO conjugating enzymes.". Mol. Cell 21 (3): 349–57. doi:10.1016/j.molcel.2005.12.019. PMID 16455490.
Li T, Santockyte R, Shen RF, et al. (2006). "A general approach for investigating enzymatic pathways and substrates for ubiquitin-like modifiers.". Arch. Biochem. Biophys. 453 (1): 70–4. doi:10.1016/j.abb.2006.03.002. PMID 16620772.
Lemos TA, Kobarg J (2006). "CGI-55 interacts with nuclear proteins and co-localizes to p80-coilin positive-coiled bodies in the nucleus.". Cell Biochem. Biophys. 44 (3): 463–74. PMID 16679534.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.