SAC (gene)

From Wikipedia, the free encyclopedia

Testicular soluble adenylyl cyclase

Identifiers

SAC; HCA2; RP1-313L4.2; SACI

External IDs

OMIM: 605205 MGI: 2660854 HomoloGene: 10188

Gene ontology
Molecular Function:	• adenylate cyclase activity • phosphorus-oxygen lyase activity
Cellular Component:	• soluble fraction • cytoplasm • cytosol
Biological Process:	• cAMP biosynthetic process • intracellular signaling cascade • cyclic nucleotide biosynthetic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_018417 (mRNA)
NP_060887 (protein)

NM_173029 (mRNA)
NP_766617 (protein)

Location

Chr 1: 166.05 - 166.15 Mb

Chr 1: 167.34 - 167.41 Mb

Pubmed search

[1]

[2]

Testicular soluble adenylyl cyclase, also known as SAC, is a human gene.^[1]

The protein encoded by this gene belongs to a distinct class of mammalian adenylyl cyclase that is soluble in testis but particulate in sperm and other tissues. It is unlike other mammalian adenylyl cyclases because it is insensitive to G protein or forskolin regulation and is directly regulated by bicarbonate. It is localized in the cytoplasm and to organelles and is thought to function as a general bicarbonate sensor throughout the body. It plays an important role in the generation of cAMP in spermatozoa, playing possible roles in sperm capacitation, hypermotility, and/or the acrosome reaction.^[1]

[edit] References

^ ^a ^b Entrez Gene: SAC testicular soluble adenylyl cyclase.

[edit] Further reading

Wuttke MS, Buck J, Levin LR (2002). "Bicarbonate-regulated soluble adenylyl cyclase.". JOP 2 (4 Suppl): 154–8. PMID 11875252.
Hukovic N, Panetta R, Kumar U, et al. (1998). "The cytoplasmic tail of the human somatostatin receptor type 5 is crucial for interaction with adenylyl cyclase and in mediating desensitization and internalization.". J. Biol. Chem. 273 (33): 21416–22. PMID 9694905.
Buck J, Sinclair ML, Schapal L, et al. (1999). "Cytosolic adenylyl cyclase defines a unique signaling molecule in mammals.". Proc. Natl. Acad. Sci. U.S.A. 96 (1): 79–84. PMID 9874775.
Hayes JS, Lawler OA, Walsh MT, Kinsella BT (1999). "The prostacyclin receptor is isoprenylated. Isoprenylation is required for efficient receptor-effector coupling.". J. Biol. Chem. 274 (34): 23707–18. PMID 10446129.
Sinclair ML, Wang XY, Mattia M, et al. (2000). "Specific expression of soluble adenylyl cyclase in male germ cells.". Mol. Reprod. Dev. 56 (1): 6–11. doi:10.1002/(SICI)1098-2795(200005)56:1<6::AID-MRD2>3.0.CO;2-M. PMID 10737962.
Chen Y, Cann MJ, Litvin TN, et al. (2000). "Soluble adenylyl cyclase as an evolutionarily conserved bicarbonate sensor.". Science 289 (5479): 625–8. PMID 10915626.
Jaiswal BS, Conti M (2001). "Identification and functional analysis of splice variants of the germ cell soluble adenylyl cyclase.". J. Biol. Chem. 276 (34): 31698–708. doi:10.1074/jbc.M011698200. PMID 11423534.
Reed BY, Gitomer WL, Heller HJ, et al. (2002). "Identification and characterization of a gene with base substitutions associated with the absorptive hypercalciuria phenotype and low spinal bone density.". J. Clin. Endocrinol. Metab. 87 (4): 1476–85. PMID 11932268.
Zippin JH, Chen Y, Nahirney P, et al. (2003). "Compartmentalization of bicarbonate-sensitive adenylyl cyclase in distinct signaling microdomains.". FASEB J. 17 (1): 82–4. doi:10.1096/fj.02-0598fje. PMID 12475901.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Litvin TN, Kamenetsky M, Zarifyan A, et al. (2003). "Kinetic properties of "soluble" adenylyl cyclase. Synergism between calcium and bicarbonate.". J. Biol. Chem. 278 (18): 15922–6. doi:10.1074/jbc.M212475200. PMID 12609998.
Jaiswal BS, Conti M (2003). "Calcium regulation of the soluble adenylyl cyclase expressed in mammalian spermatozoa.". Proc. Natl. Acad. Sci. U.S.A. 100 (19): 10676–81. doi:10.1073/pnas.1831008100. PMID 12958208.
Marjanovic JA, Li Z, Stojanovic A, Du X (2006). "Stimulatory roles of nitric-oxide synthase 3 and guanylyl cyclase in platelet activation.". J. Biol. Chem. 280 (45): 37430–8. doi:10.1074/jbc.M506518200. PMID 16144836.
Schmid A, Sutto Z, Nlend MC, et al. (2007). "Soluble adenylyl cyclase is localized to cilia and contributes to ciliary beat frequency regulation via production of cAMP.". J. Gen. Physiol. 130 (1): 99–109. doi:10.1085/jgp.200709784. PMID 17591988.