S100A3

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S100 calcium binding protein A3
PDB rendering based on 1kso.
Available structures: 1kso
Identifiers
Symbol(s) S100A3; S100E
External IDs OMIM: 176992 MGI: 1338849 HomoloGene: 2223
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 6274 20197
Ensembl ENSG00000188015 ENSMUSG00000001021
Uniprot P33764 Q496W1
Refseq NM_002960 (mRNA)
NP_002951 (protein)		 NM_011310 (mRNA)
NP_035440 (protein)
Location Chr 1: 151.79 - 151.79 Mb Chr 3: 90.67 - 90.69 Mb
Pubmed search [1] [2]

S100 calcium binding protein A3, also known as S100A3, is a human gene.[1]

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein has the highest content of cysteines of all S100 proteins, has a high affinity for Zinc, and is highly expressed in human hair cuticle. The precise function of this protein is unknown.[1]

[edit] References

  1. ^ a b Entrez Gene: S100A3 S100 calcium binding protein A3.

[edit] Further reading

  • Schäfer BW, Heizmann CW (1996). "The S100 family of EF-hand calcium-binding proteins: functions and pathology.". Trends Biochem. Sci. 21 (4): 134–40. PMID 8701470. 
  • Föhr UG, Heizmann CW, Engelkamp D, et al. (1995). "Purification and cation binding properties of the recombinant human S100 calcium-binding protein A3, an EF-hand motif protein with high affinity for zinc.". J. Biol. Chem. 270 (36): 21056–61. PMID 7673133. 
  • Schäfer BW, Wicki R, Engelkamp D, et al. (1995). "Isolation of a YAC clone covering a cluster of nine S100 genes on human chromosome 1q21: rationale for a new nomenclature of the S100 calcium-binding protein family.". Genomics 25 (3): 638–43. PMID 7759097. 
  • Engelkamp D, Schäfer BW, Mattei MG, et al. (1993). "Six S100 genes are clustered on human chromosome 1q21: identification of two genes coding for the two previously unreported calcium-binding proteins S100D and S100E.". Proc. Natl. Acad. Sci. U.S.A. 90 (14): 6547–51. PMID 8341667. 
  • Kizawa K, Uchiwa H, Murakami U (1996). "Highly-expressed S100A3, a calcium-binding protein, in human hair cuticle.". Biochim. Biophys. Acta 1312 (2): 94–8. PMID 8672544. 
  • Böni R, Burg G, Doguoglu A, et al. (1997). "Immunohistochemical localization of the Ca2+ binding S100 proteins in normal human skin and melanocytic lesions.". Br. J. Dermatol. 137 (1): 39–43. PMID 9274623. 
  • Groves P, Finn BE, Kuźnicki J, Forsén S (1998). "A model for target protein binding to calcium-activated S100 dimers.". FEBS Lett. 421 (3): 175–9. PMID 9468301. 
  • Ridinger K, Ilg EC, Niggli FK, et al. (1999). "Clustered organization of S100 genes in human and mouse.". Biochim. Biophys. Acta 1448 (2): 254–63. PMID 9920416. 
  • Fritz G, Heizmann CW, Kroneck PM (1999). "Probing the structure of the human Ca2+- and Zn2+-binding protein S100A3: spectroscopic investigations of its transition metal ion complexes, and three-dimensional structural model.". Biochim. Biophys. Acta 1448 (2): 264–76. PMID 9920417. 
  • Hoyaux D, Decaestecker C, Heizmann CW, et al. (2000). "S100 proteins in Corpora amylacea from normal human brain.". Brain Res. 867 (1-2): 280–8. PMID 10837826. 
  • Fritz G, Mittl PR, Vasak M, et al. (2002). "The crystal structure of metal-free human EF-hand protein S100A3 at 1.7-A resolution.". J. Biol. Chem. 277 (36): 33092–8. doi:10.1074/jbc.M200574200. PMID 12045193. 
  • Mittl PR, Fritz G, Sargent DF, et al. (2003). "Metal-free MIRAS phasing: structure of apo-S100A3.". Acta Crystallogr. D Biol. Crystallogr. 58 (Pt 8): 1255–61. PMID 12136135. 
  • Kizawa K, Troxler H, Kleinert P, et al. (2003). "Characterization of the cysteine-rich calcium-binding S100A3 protein from human hair cuticles.". Biochem. Biophys. Res. Commun. 299 (5): 857–62. PMID 12470658. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
  • Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414. 
  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931. 
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