S-methyl-5-thioribose kinase

From Wikipedia, the free encyclopedia

In enzymology, a S-methyl-5-thioribose kinase (EC 2.7.1.100) is an enzyme that catalyzes the chemical reaction

ATP + S-methyl-5-thio-D-ribose $\rightleftharpoons$ ADP + S-methyl-5-thio-alpha-D-ribose 1-phosphate

Thus, the two substrates of this enzyme are ATP and S-methyl-5-thio-D-ribose, whereas its two products are ADP and S-methyl-5-thio-alpha-D-ribose 1-phosphate.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:S-methylmethyl-5-thio-D-ribose 1-phosphotransferase. Other names in common use include 5-methylthioribose kinase (phosphorylating), methylthioribose kinase, 5-methylthioribose kinase, and ATP:S5-methyl-5-thio-D-ribose 1-phosphotransferase. This enzyme participates in methionine metabolism.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 6 structures have been solved for this class of enzymes, with PDB accession codes 2OLC, 2PU8, 2PUI, 2PUL, 2PUN, and 2PUP.

[edit] References

IUBMB entry for 2.7.1.100
BRENDA references for 2.7.1.100 (Recommended.)
PubMed references for 2.7.1.100
PubMed Central references for 2.7.1.100
Google Scholar references for 2.7.1.100
Ferro AJ, Barrett A, Shapiro SK (1978). "5-Methylthioribose kinase. A new enzyme involved in the formation of methionine from 5-methylthioribose". J. Biol. Chem. 253: 6021–5. PMID 210167.
Guranowski A (1983). "Plant 5-methylthioribose kinase". Plant Physiol. 71: 932–935.