Talk:S-Adenosyl methionine

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Contents 1 Merge from S-adenosylmethionine 2 Cleanup 3 Misc 4 degradation and dosage 5 dosage 6 Salt forms 7 Possible copyvio in "Usage" section 8 Dead link

[edit] Merge from S-adenosylmethionine

I have added a mergefrom. Shouldn't be hard to do! --Slashme 11:33, 28 November 2005 (UTC)

Done Kcordina 09:22, 16 March 2006 (UTC)

I've yet to read a tutorial on how to redirect a query to a specific page, so I was hoping that someone could assist me. SAMe is also known as 'ademetionine' - and searching for it should redirect you to this article on SAMe - irrespective of whether 'ademetionine' is merely employed by supplement companies to sound pharmaceutical (I'm unclear about the legitimacy of the word) substantiate 15 Feb 2007

added a redirect --Substantiate 02:03, 17 February 2007 (UTC)

[edit] Cleanup

I will have a look at cleaning this up some time! --Slashme 11:33, 28 November 2005 (UTC)

I've made a start on cleaning this up, and will need to begin adding references. As you can tell, I'm better at the biochemistry side than the supplement section. --TimVickers 16:35, 25 June 2006 (UTC)

I added a reference from the Am J Psychiatry re depression efficacy --Substantiate 02:05, 17 February 2007 (UTC)

[edit] Misc

Sure I don't know how to add hyperlinking or add references that only authorized people may have access to. -RS

The comment below was copied from Talk:S-adenosylmethionine during merging. Kcordina 09:22, 16 March 2006 (UTC)

I'm pretty new to Wikipedia, but "being bold." I added the pharmocology stub tag to this article, in the hope that Wikipedians with relevant expertise will expand it. SAM-e is taken for depression and joint pains. It is prescribed in Europe, but can be purchased in the US over the counter in supplement stores. It is generally quite expensive. Because it has become a trendy anti-depressant (usually self-prescribed in the US), I feel that it is important to give people more information about this supplement. It has medical advocates, most notably Dr. Richard Brown (author of "Stop Depression Now"), but I have come across many articles advising caution, as long-term effects are not established. Of most concern is that the supplement breaks down to homocysteine, high levels of which are apparently sometimes indicative of (or causative??) of heart disease.

As with so many supplements, a Google search is flooded with very positive explanations of this supplement by companies selling it. The few negative articles are by medical experts who often seem to reject it reflexively, because its effectiveness has not yet been adequately researched. There is a real need for an objective, in-depth summary of how this supplement works, and what is known about its effectiveness and side effects.

I am not a medical or pharmacological expert, even remotely, so I labeled this a stub in hopes that someone who has expertise in a relevant field can expand it. (StrangeAttractor 15:47, 10 December 2005 (UTC))

Although this article and many others state that SAM-e is invoplved in the synthesis of dopamine and serotonin (others add epinephrine or norepinephrine), the metabolic pathway is not described, neither here nore under the articles refering to the respective neurotransmitters. Thye synthesis pathways for dopamine and serotonin which are given in their respective articles do not mention either SAM-e or methylation. I think it would be good to understand what role SAM-e plays in those synthesis paths, and especially whether it plays a role in the rate-limiting step. 66.245.159.152 20:49, 6 March 2007 (UTC)Andrew Hoerner

[edit] degradation and dosage

"SAM is still liable to degradation leading to distributors that may advertise a dose higher than what is actually being ingested." I'm not sure what this is saying. Are you saying the maker, for example, puts 400mg in the tablet and prints 400mg on the box and then you get 300mg due to degredation? (I just got Zentonil 400 for my dog today.) --Gbleem 20:45, 22 April 2006 (UTC)

Yes. It appears that SAMe is somewhat difficult to make and has poor stability. Most articles suggest the blister packs and enteric coating to improve stability but I can not find any research to back this up. Some articles recommend against refrideration but the best article used it and documented the degradation with time.

The various companies have developed newer salt forms but this may have been mainly an attempt to avoid other patents. I can find very little (almost no) information comparing off the shelf potency of various salt forms, their stability, and bioavailablity.

—Who123 17:41, 8 December 2006 (UTC)

[edit] dosage

though i've yet to find a reliable source to site via internet, the therapeutic dose of SAMe is not usually 800-1600mg/day. in fact it is usually 200mg/day. 1600mg would be considered a very large dose. —The preceding unsigned comment was added by Harlequence (talk • contribs) 01:28, 17 January 2007 (UTC).

for depression, dosages in the range of 800 - 1600mg would be considered therapeutic. run a pubmed search and note the abstracts that used oral administration, i.e. Obstetrics and Gynecology Department, University La Sapienza School of Medicine, Rome, Italy.

S-adenosyl-L-methionine (SAMe) is a naturally occurring substance which is a major source of methyl groups in the brain and has been found in previous studies to be an effective antidepressant. The aim of this study was to assess the efficacy of oral SAMe in the treatment of depressed postmenopausal women in a 30-day double-blind placebo-controlled randomized trial. During the course of the study, 80 women, between the ages of 45 and 59, who were diagnosed as having DSM-III-R major depressive disorder or dysthymia between 6 and 36 months following either natural menopause or hysterectomy, underwent 1 week of single-blind placebo washout, followed by 30 days of double-blind treatment with either SAMe 1,600 mg/day or placebo. There was a significantly greater improvement in depressive symptoms in the group treated with SAMe compared to the placebo group from day 10 of the study. Side effects were mild and transient.

also, http://www.umm.edu/altmed/ConsSupplements/SAdenosylmethionineSAMecs.html, an excellent, objective resource for information on 'alternative medicine' that is provided by the University of Maryland Medical Center notes that:

Depression: The majority of studies have used between 800 and 1,600 mg of SAMe per day for depression. The daily dosage is typically split between morning and afternoon. --Substantiate 01:28, 17 February 2007 (UTC)

Are these dosages for the tosylate or butanedisulfonate salt? The latter is strongly reccomended in this areticle but is now almost impossible to find in the U.S. 66.245.159.152 20:40, 6 March 2007 (UTC)Andrew Hoerner

[edit] Salt forms

We presently list the various salt forms along with (what appears to be?) the manufacturers that supply each. Or the commercial/brand-names that have them (I don't even know what some of the named companies are). The adjacent cite (University of Maryland Medical Center webpage) seems to be silent on the whole issue of suppliers, so that ref seems misplaced and the whole "who supplies what" uncited. I'm not sure it's worthy content (WP not a product directory) but it might be useful; I have no objection to keeping it with proper citation. Or is there some external product guide that we could just link? DMacks 20:36, 25 April 2007 (UTC)

Hi. There was not enough room but the revert was to: 16:10, April 25, 2007 DMacks. The reference does support multiple forms: "Available Forms: S-adenosylmethionine butanedisulfonate S-adenosylmethionine disulfate ditosylate S-adenosylmethionine disulfate tosylate S-adenosylmethionine tosylate". In order to provide the information as to which manufacturer is using which form one must go to the manufacturers sites. These could be included.—Who123 20:51, 25 April 2007 (UTC)

I think that it is ridiculous to cite a 1999 Newsweek article as evidence that the butanedisulfonate salt is more stable than other salts. Also, the next sentence in the Oral Forms section states that butanedisulfonate is 5% bioavailable compared to 1% for tosylate, but the reference [Stramentinoli 1979] has no comparison of the two products, and is an animal study anyway. Unless someone can come back with better evidence by the end of January I am going to rewrite the entire section.David notMD (talk) 20:09, 23 January 2008 (UTC)

[edit] Possible copyvio in "Usage" section

The "Usage" section is in need of a major rewriting...it's written as an instruction manual, not an encyclopedia entry. While reading the refs to figure out what was actually supported, I noticed that even worse, our section is nearly verbatim copy of the cited wholehealthmd ref, so I'm commenting it out until at least the copyvio issue can be resolved. DMacks 21:42, 25 April 2007 (UTC)

It may be more helpful to re-write aspects to improve them rather than commenting the section out. With the section commented out, it is difficult to improve.—Who123 22:40, 25 April 2007 (UTC)

I have rewritten the section. If it is thought that the section no longer potentially violates copyright then the tag should be removed.—Who123 23:26, 25 April 2007 (UTC)

Looks much better. I just worked on it some more too...now it's clearly not copyvio. I would have worked on it if I'd had time when I first noticed it, but otherwise, "remove copyrighted material" is always a viable thing to do per WP:COPYVIO policy. DMacks 00:10, 26 April 2007 (UTC)

I agree that it is much better. I think it is better to rewrite to avoid potential copyvio than lose information. Thanks!—Who123 02:15, 26 April 2007 (UTC)

I cut parts from the Usage section. Brands should not be identified as using specific salt forms because companies will change formulas based on changes to cost of ingredients. Also, there is no clear evidence that one salt form is superior to another, either for stability or absorption.David notMD (talk) 21:37, 30 January 2008 (UTC)

[edit] Dead link

Guys, the link http://www.umm.edu/altmed/ConsSupplements/SAdenosylmethionineSAMecs.html is dead. Thought you'd like to know. —Preceding unsigned comment added by 167.206.188.3 (talk)

Thanks for noticing that! I changed the article's link to point to (what I think is) the same page on their re-organized webdite. DMacks 22:42, 9 July 2007 (UTC)