Talk:Ryanodine receptor

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To write this, I will need to read PMID 15336975 JFW | T@lk 14:24, 9 May 2005 (UTC)

Here's a good source: http://pharmrev.aspetjournals.org/cgi/content/full/49/1/1 KBi 04:53, 15 November 2005 (UTC)

Wouldn't you add the full academic references and cite the key points in the article? JFW | T@lk 07:51, 15 November 2005 (UTC)
You're evil! It's 51 pages long! JFW | T@lk 20:12, 15 November 2005 (UTC)

[edit] From signal transduction

This should be incorporated here:

  • The ryanodine receptor is named after the plant alkaloid ryanodine. It is similar to the InsP3 receptor and stimulated to transport Ca2+ into the cytosol by recognizing Ca2+ on its cytosolic side, thus establishing a feedback mechanism; a small amount of Ca2+ in the cytosol near the receptor will cause it to release even more Ca2+. It is especially important in neurons and muscle cells. In heart and pancreas cells, another second messenger (cyclic ADP ribose) takes part in the receptor activation.

The localized and time-limited activity of Ca2+ in the cytosol is also called a Ca2+ wave. The building of the wave is done by

  • the feedback mechanism of the ryanodine receptor and
  • the activation of phospholipase C by Ca2+, which leads to the production of inositol triphosphate, which in turn activates the InsP3 receptor.

JFW | T@lk 18:27, 9 May 2005 (UTC)

Im pretty sure that myasthenia gravis is a disease caused by antibodies against Ach receptors

Sure, but the 10% who are negative often have antibodies against other skeletal muscle proteins, such as MuSK and apparently also RyR1. JFW | T@lk 10:08, 26 March 2008 (UTC)

Why is there no article about the DHP receptor? 129.31.72.52 13:50, 20 May 2007 (UTC)

WP:BOLD, create it! Or rather, get a username and then create it. JFW | T@lk 10:08, 26 March 2008 (UTC)

[edit] Calcium-induced calcium release

Don't you think this process fundamental to cardiac physiology requires its own page (i.e. it doesn't redirect to this ryanodine receptor article)? Butterfly reflections 04:15, 27 May 2007 (UTC)

{{sofixit}} JFW | T@lk 10:08, 26 March 2008 (UTC)

[edit] Muscle fatigue

RYR1 apparently plays a significant role in muscle fatigue: doi:10.1172/JCI34006 JFW | T@lk 10:08, 26 March 2008 (UTC)