RTN2

From Wikipedia, the free encyclopedia

Reticulon 2

Identifiers

RTN2; NSP2; NSPL1

External IDs

OMIM: 603183 MGI: 107612 HomoloGene: 32180

Gene ontology
Molecular Function:	• signal transducer activity
Cellular Component:	• endoplasmic reticulum • membrane • integral to membrane • integral to endoplasmic reticulum membrane
Biological Process:	• signal transduction

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_005619 (mRNA)
NP_005610 (protein)

XM_984973 (mRNA)
XP_990067 (protein)

Location

Chr 19: 50.68 - 50.69 Mb

Chr 7: 18.44 - 18.45 Mb

Pubmed search

[1]

[2]

Reticulon 2, also known as RTN2, is a human gene.^[1]

This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. Alternatively spliced transcript variants encoding different isoforms have been identified.^[1]

[edit] References

^ ^a ^b Entrez Gene: RTN2 reticulon 2.

[edit] Further reading

Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain.". Mol. Cell Proteomics 3 (11): 1093-101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
He W, Lu Y, Qahwash I, et al. (2004). "Reticulon family members modulate BACE1 activity and amyloid-beta peptide generation.". Nat. Med. 10 (9): 959-65. doi:10.1038/nm1088. PMID 15286784.
Reuter TY, Medhurst AL, Waisfisz Q, et al. (2003). "Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport.". Exp. Cell Res. 289 (2): 211-21. PMID 14499622.
Oertle T, Klinger M, Stuermer CA, Schwab ME (2003). "A reticular rhapsody: phylogenic evolution and nomenclature of the RTN/Nogo gene family.". FASEB J. 17 (10): 1238-47. doi:10.1096/fj.02-1166hyp. PMID 12832288.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Geisler JG, Palmer RJ, Stubbs LJ, Mucenski ML (2000). "Nspl1, a new Z-band-associated protein.". J. Muscle Res. Cell. Motil. 20 (7): 661-8. PMID 10672514.
Roebroek AJ, Contreras B, Pauli IG, Van de Ven WJ (1998). "cDNA cloning, genomic organization, and expression of the human RTN2 gene, a member of a gene family encoding reticulons.". Genomics 51 (1): 98-106. doi:10.1006/geno.1997.5175. PMID 9693037.
Geisler JG, Stubbs LJ, Wasserman WW, Mucenski ML (1998). "Molecular cloning of a novel mouse gene with predominant muscle and neural expression.". Mamm. Genome 9 (4): 274-82. PMID 9530622.
Stubbs L, Carver EA, Shannon ME, et al. (1996). "Detailed comparative map of human chromosome 19q and related regions of the mouse genome.". Genomics 35 (3): 499-508. doi:10.1006/geno.1996.0390. PMID 8812484.