RTN1

From Wikipedia, the free encyclopedia

Reticulon 1

Identifiers

RTN1; MGC133250; NSP

External IDs

OMIM: 600865 MGI: 1933947 HomoloGene: 49654

Gene ontology
Molecular Function:	• signal transducer activity
Cellular Component:	• endoplasmic reticulum • membrane • integral to membrane • integral to endoplasmic reticulum membrane
Biological Process:	• signal transduction • neuron differentiation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_021136 (mRNA)
NP_066959 (protein)

NM_001007596 (mRNA)
NP_001007597 (protein)

Location

Chr 14: 59.13 - 59.41 Mb

Chr 12: 73.13 - 73.33 Mb

Pubmed search

[1]

[2]

Reticulon 1, also known as RTN1, is a human gene.^[1]

This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. Alternatively spliced transcript variants encoding different isoforms have been identified. Multiple promoters rather than alternative splicing of internal exons seem to be involved in this diversity.^[1]

[edit] References

^ ^a ^b Entrez Gene: RTN1 reticulon 1.

[edit] Further reading

Senden NH, van de Velde HJ, Broers JL, et al. (1994). "Cluster-10 lung-cancer antibodies recognize NSPs, novel neuro-endocrine proteins associated with membranes of the endoplasmic reticulum.". Int. J. Cancer Suppl. 8: 84-8. PMID 7515034.
Roebroek AJ, van de Velde HJ, Van Bokhoven A, et al. (1993). "Cloning and expression of alternative transcripts of a novel neuroendocrine-specific gene and identification of its 135-kDa translational product.". J. Biol. Chem. 268 (18): 13439-47. PMID 7685762.
van de Velde HJ, Roebroek AJ, Senden NH, et al. (1995). "NSP-encoded reticulons, neuroendocrine proteins of a novel gene family associated with membranes of the endoplasmic reticulum.". J. Cell. Sci. 107 ( Pt 9): 2403-16. PMID 7844160.
van de Velde HJ, Senden NH, Roskams TA, et al. (1994). "NSP-encoded reticulons are neuroendocrine markers of a novel category in human lung cancer diagnosis.". Cancer Res. 54 (17): 4769-76. PMID 8062278.
Kools PF, Roebroek AJ, Van de Velde HJ, et al. (1994). "Regional mapping of the human NSP gene to chromosome region 14q21-->q22 by fluorescence in situ hybridization analysis.". Cytogenet. Cell Genet. 66 (1): 48-50. PMID 8275708.
Roebroek AJ, Ayoubi TA, Van de Velde HJ, et al. (1997). "Genomic organization of the human NSP gene, prototype of a novel gene family encoding reticulons.". Genomics 32 (2): 191-9. doi:10.1006/geno.1996.0105. PMID 8833145.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791-806. PMID 8889548.
Senden NH, Timmer ED, Boers JE, et al. (1996). "Neuroendocrine-specific protein C (NSP-C): subcellular localization and differential expression in relation to NSP-A.". Eur. J. Cell Biol. 69 (3): 197-213. PMID 8900485.
Hens J, Nuydens R, Geerts H, et al. (1998). "Neuronal differentiation is accompanied by NSP-C expression.". Cell Tissue Res. 292 (2): 229-37. PMID 9560466.
Tagami S, Eguchi Y, Kinoshita M, et al. (2001). "A novel protein, RTN-XS, interacts with both Bcl-XL and Bcl-2 on endoplasmic reticulum and reduces their anti-apoptotic activity.". Oncogene 19 (50): 5736-46. doi:10.1038/sj.onc.1203948. PMID 11126360.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Oertle T, Klinger M, Stuermer CA, Schwab ME (2003). "A reticular rhapsody: phylogenic evolution and nomenclature of the RTN/Nogo gene family.". FASEB J. 17 (10): 1238-47. doi:10.1096/fj.02-1166hyp. PMID 12832288.
Di Sano F, Fazi B, Citro G, et al. (2003). "Glucosylceramide synthase and its functional interaction with RTN-1C regulate chemotherapeutic-induced apoptosis in neuroepithelioma cells.". Cancer Res. 63 (14): 3860-5. PMID 12873973.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Iwahashi J, Hamada N (2004). "Human reticulon 1-A and 1-B interact with a medium chain of the AP-2 adaptor complex.". Cell. Mol. Biol. (Noisy-le-grand) 49 Online Pub: OL467-71. PMID 14995077.
Hu Y, Fang X, Dunham SM, et al. (2004). "90-kDa ribosomal S6 kinase is a direct target for the nuclear fibroblast growth factor receptor 1 (FGFR1): role in FGFR1 signaling.". J. Biol. Chem. 279 (28): 29325-35. doi:10.1074/jbc.M311144200. PMID 15117958.
He W, Lu Y, Qahwash I, et al. (2004). "Reticulon family members modulate BACE1 activity and amyloid-beta peptide generation.". Nat. Med. 10 (9): 959-65. doi:10.1038/nm1088. PMID 15286784.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.
Mannan AU, Boehm J, Sauter SM, et al. (2007). "Spastin, the most commonly mutated protein in hereditary spastic paraplegia interacts with Reticulon 1 an endoplasmic reticulum protein.". Neurogenetics 7 (2): 93-103. doi:10.1007/s10048-006-0034-4. PMID 16602018.