RSPO3

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R-spondin 3 homolog (Xenopus laevis)
Identifiers
Symbol(s) RSPO3; CRISTIN1; FLJ14440; PWTSR; THSD2
External IDs OMIM: 610574 MGI: 1920030 HomoloGene: 12484
Orthologs
Human Mouse
Entrez 84870 72780
Ensembl ENSG00000146374 ENSMUSG00000019880
Uniprot Q9BXY4 Q2TJ95
Refseq NM_032784 (mRNA)
NP_116173 (protein)		 XM_622780 (mRNA)
XP_622780 (protein)
Location Chr 6: 127.48 - 127.56 Mb Chr 10: 29.14 - 29.23 Mb
Pubmed search [1] [2]

R-spondin 3 homolog (Xenopus laevis), also known as RSPO3, is a human gene.[1]

This gene encodes a member of the thrombospondin type 1 repeat supergene family. In addition, the protein contains a furin-like cysteine-rich region. Furin-like repeat domains have been found in a variety of eukaryotic proteins involved in the mechanism of signal transduction by receptor tyrosine kinases.[1]

[edit] References

  1. ^ a b Entrez Gene: RSPO3 R-spondin 3 homolog (Xenopus laevis).

[edit] Further reading

  • Adams JC, Tucker RP (2000). "The thrombospondin type 1 repeat (TSR) superfamily: diverse proteins with related roles in neuronal development.". Dev. Dyn. 218 (2): 280-99. doi:10.1002/(SICI)1097-0177(200006)218:2<280::AID-DVDY4>3.0.CO;2-0. PMID 10842357. 
  • Kim KA, Zhao J, Andarmani S, et al. (2006). "R-Spondin proteins: a novel link to beta-catenin activation.". Cell Cycle 5 (1): 23-6. PMID 16357527. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039. 
  • Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805-11. doi:10.1038/nature02055. PMID 14574404. 
  • Hannah BL, Misenheimer TM, Annis DS, Mosher DF (2003). "A polymorphism in thrombospondin-1 associated with familial premature coronary heart disease causes a local change in conformation of the Ca2+-binding repeats.". J. Biol. Chem. 278 (11): 8929-34. PMID 12643280. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Chen JZ, Wang S, Tang R, et al. (2003). "Cloning and identification of a cDNA that encodes a novel human protein with thrombospondin type I repeat domain, hPWTSR.". Mol. Biol. Rep. 29 (3): 287-92. PMID 12463421. 
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