RSPO1

From Wikipedia, the free encyclopedia

R-spondin homolog (Xenopus laevis)

Identifiers

RSPO1; FLJ40906; RP11-566C13.1

External IDs

OMIM: 609595 MGI: 2183426 HomoloGene: 52148

Gene ontology
Molecular Function:	• iron ion binding • heparin binding • electron carrier activity
Cellular Component:	• extracellular space
Biological Process:	• electron transport • Wnt receptor signaling pathway • response to stimulus

Orthologs

Human

Mouse

Refseq

NM_001038633 (mRNA)
NP_001033722 (protein)

XM_980712 (mRNA)
XP_985806 (protein)

Location

Chr 1: 37.85 - 37.87 Mb

Chr 4: 124.49 - 124.51 Mb

Pubmed search

[1]

[2]

R-spondin homolog (Xenopus laevis), also known as RSPO1, is a human gene.^[1]

This gene is a member of the R-spondin family and encodes a secreted activator protein with two cystein-rich, furin-like domains and one thrombospondin type 1 domain. In mice, the protein induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy-induced adverse effects.^[1]

[edit] References

^ ^a ^b Entrez Gene: RSPO1 R-spondin homolog (Xenopus laevis).

[edit] Further reading

Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Kamata T, Katsube K, Michikawa M, et al. (2004). "R-spondin, a novel gene with thrombospondin type 1 domain, was expressed in the dorsal neural tube and affected in Wnts mutants.". Biochim. Biophys. Acta 1676 (1): 51-62. PMID 14732490.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Kim KA, Kakitani M, Zhao J, et al. (2005). "Mitogenic influence of human R-spondin1 on the intestinal epithelium.". Science 309 (5738): 1256-9. doi:10.1126/science.1112521. PMID 16109882.
Abraham C, Cho JH (2005). "Inducing intestinal growth.". N. Engl. J. Med. 353 (21): 2297-9. doi:10.1056/NEJMcibr053367. PMID 16306530.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55-65. doi:10.1101/gr.4039406. PMID 16344560.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315-21. doi:10.1038/nature04727. PMID 16710414.
Parma P, Radi O, Vidal V, et al. (2007). "R-spondin1 is essential in sex determination, skin differentiation and malignancy.". Nat. Genet. 38 (11): 1304-9. doi:10.1038/ng1907. PMID 17041600.
Binnerts ME, Kim KA, Bright JM, et al. (2007). "R-Spondin1 regulates Wnt signaling by inhibiting internalization of LRP6.". Proc. Natl. Acad. Sci. U.S.A. 104 (37): 14700-5. doi:10.1073/pnas.0702305104. PMID 17804805.