RS 67333

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RS 67333
RS 67333
IUPAC name 1-(4-Amino-5-chloro-2-methoxyphenyl)-

3-(1-butyl-4-piperidinyl)-1-propanone
Identifiers
CAS number [160845-95-4]
SMILES C(CCC1CCN(CC1)CCCC)(=O)c1c(cc(c(c1)Cl)N)OC
Properties
Molecular formula C19H29N2O2Cl
Molar mass 352.9 g/mol
Except where noted otherwise, data are given for
materials in their standard state
(at 25 °C, 100 kPa)
Infobox disclaimer and references

RS 67333 is a 5-HT4 receptor partial agonist, being researched as a possible rapid acting antidepressant[1], nootropic[2], and treatment for Alzheimer's[3].

[edit] References

  1. ^ Lucas G, Rymar VV, Du J, Mnie-Filali O, Bisgaard C, Manta S, Lambas-Senas L, Wiborg O, Haddjeri N, Piñeyro G, Sadikot AF, Debonnel G. (2007). "Serotonin(4) (5-HT(4)) Receptor Agonists Are Putative Antidepressants with a Rapid Onset of Action.". Neuron. 55 (5): 712–25. doi:10.1016/j.neuron.2007.07.041. PMID 17785179. 
  2. ^ Lamirault L, Simon H. (2001). "Enhancement of place and object recognition memory in young adult and old rats by RS 67333, a partial agonist of 5-HT4 receptors.". Neuropharmacology. 41 (7): 844–53. doi:10.1016/S0028-3908(01)00123-X. PMID 11684148. 
  3. ^ Cho S, Hu Y. (2007). "Activation of 5-HT4 receptors inhibits secretion of beta-amyloid peptides and increases neuronal survival.". Experimental Neurology. 203 (1): 274–8. doi:10.1016/j.expneurol.2006.07.021. PMID 16978609. 
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