RPS6KB2

From Wikipedia, the free encyclopedia

Ribosomal protein S6 kinase, 70kDa, polypeptide 2

Identifiers

RPS6KB2; KLS; P70-beta; P70-beta-1; P70-beta-2; S6K-beta2; S6K2; SRK; STK14B; p70(S6K)-beta; p70S6Kb

External IDs

OMIM: 608939 MGI: 1927343 HomoloGene: 68374

Gene ontology
Molecular Function:	• nucleotide binding • protein kinase activity • protein serine/threonine kinase activity • ATP binding • transferase activity
Biological Process:	• regulation of progression through cell cycle • translation • protein amino acid phosphorylation • signal transduction

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001007071 (mRNA)
NP_001007072 (protein)

NM_021485 (mRNA)
NP_067460 (protein)

Location

Chr 11: 66.95 - 66.96 Mb

Chr 19: 4.15 - 4.16 Mb

Pubmed search

[1]

[2]

Ribosomal protein S6 kinase, 70kDa, polypeptide 2, also known as RPS6KB2, is a human gene.^[1]

This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates the S6 ribosomal protein and eucaryotic translation initiation factor 4B (eIF4B). Phosphorylation of S6 leads to an increase in protein synthesis and cell proliferation.^[1]

[edit] References

^ ^a ^b Entrez Gene: RPS6KB2 ribosomal protein S6 kinase, 70kDa, polypeptide 2.

[edit] Further reading

Gout I, Minami T, Hara K, et al. (1998). "Molecular cloning and characterization of a novel p70 S6 kinase, p70 S6 kinase beta containing a proline-rich region.". J. Biol. Chem. 273 (46): 30061-4. PMID 9804755.
Saitoh M, ten Dijke P, Miyazono K, Ichijo H (1999). "Cloning and characterization of p70(S6K beta) defines a novel family of p70 S6 kinases.". Biochem. Biophys. Res. Commun. 253 (2): 470-6. doi:10.1006/bbrc.1998.9784. PMID 9878560.
Lee-Fruman KK, Kuo CJ, Lippincott J, et al. (1999). "Characterization of S6K2, a novel kinase homologous to S6K1.". Oncogene 18 (36): 5108-14. doi:10.1038/sj.onc.1202894. PMID 10490847.
Koh H, Jee K, Lee B, et al. (1999). "Cloning and characterization of a nuclear S6 kinase, S6 kinase-related kinase (SRK); a novel nuclear target of Akt.". Oncogene 18 (36): 5115-9. doi:10.1038/sj.onc.1202895. PMID 10490848.
Martin KA, Schalm SS, Richardson C, et al. (2001). "Regulation of ribosomal S6 kinase 2 by effectors of the phosphoinositide 3-kinase pathway.". J. Biol. Chem. 276 (11): 7884-91. doi:10.1074/jbc.M006969200. PMID 11108711.
Martin KA, Schalm SS, Romanelli A, et al. (2001). "Ribosomal S6 kinase 2 inhibition by a potent C-terminal repressor domain is relieved by mitogen-activated protein-extracellular signal-regulated kinase kinase-regulated phosphorylation.". J. Biol. Chem. 276 (11): 7892-8. doi:10.1074/jbc.M009972200. PMID 11108720.
Minami T, Hara K, Oshiro N, et al. (2002). "Distinct regulatory mechanism for p70 S6 kinase beta from that for p70 S6 kinase alpha.". Genes Cells 6 (11): 1003-15. PMID 11733037.
Pardo OE, Arcaro A, Salerno G, et al. (2002). "Novel cross talk between MEK and S6K2 in FGF-2 induced proliferation of SCLC cells.". Oncogene 20 (52): 7658-67. doi:10.1038/sj.onc.1204994. PMID 11753643.
Park IH, Bachmann R, Shirazi H, Chen J (2002). "Regulation of ribosomal S6 kinase 2 by mammalian target of rapamycin.". J. Biol. Chem. 277 (35): 31423-9. doi:10.1074/jbc.M204080200. PMID 12087098.
Kanayasu-Toyoda T, Yamaguchi T, Oshizawa T, et al. (2002). "Role of the p70 S6 kinase cascade in neutrophilic differentiation and proliferation of HL-60 cells-a study of transferrin receptor-positive and -negative cells obtained from dimethyl sulfoxide- or retinoic acid-treated HL-60 cells.". Arch. Biochem. Biophys. 405 (1): 21-31. PMID 12176053.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Valovka T, Verdier F, Cramer R, et al. (2003). "Protein kinase C phosphorylates ribosomal protein S6 kinase betaII and regulates its subcellular localization.". Mol. Cell. Biol. 23 (3): 852-63. PMID 12529391.
Levy Y, Ronen D, Bershadsky AD, Zick Y (2003). "Sustained induction of ERK, protein kinase B, and p70 S6 kinase regulates cell spreading and formation of F-actin microspikes upon ligation of integrins by galectin-8, a mammalian lectin.". J. Biol. Chem. 278 (16): 14533-42. doi:10.1074/jbc.M207380200. PMID 12569102.
Phin S, Kupferwasser D, Lam J, Lee-Fruman KK (2003). "Mutational analysis of ribosomal S6 kinase 2 shows differential regulation of its kinase activity from that of ribosomal S6 kinase 1.". Biochem. J. 373 (Pt 2): 583-91. doi:10.1042/BJ20021794. PMID 12713446.
Kanayasu-Toyoda T, Yamaguchi T, Oshizawa T, et al. (2003). "The role of c-Myc on granulocyte colony-stimulating factor-dependent neutrophilic proliferation and differentiation of HL-60 cells.". Biochem. Pharmacol. 66 (1): 133-40. PMID 12818373.
An WL, Cowburn RF, Li L, et al. (2003). "Up-regulation of phosphorylated/activated p70 S6 kinase and its relationship to neurofibrillary pathology in Alzheimer's disease.". Am. J. Pathol. 163 (2): 591-607. PMID 12875979.
Shao J, Evers BM, Sheng H (2004). "Roles of phosphatidylinositol 3'-kinase and mammalian target of rapamycin/p70 ribosomal protein S6 kinase in K-Ras-mediated transformation of intestinal epithelial cells.". Cancer Res. 64 (1): 229-35. PMID 14729629.
Lekmine F, Sassano A, Uddin S, et al. (2004). "Interferon-gamma engages the p70 S6 kinase to regulate phosphorylation of the 40S S6 ribosomal protein.". Exp. Cell Res. 295 (1): 173-82. doi:10.1016/j.yexcr.2003.12.021. PMID 15051500.
Raught B, Peiretti F, Gingras AC, et al. (2005). "Phosphorylation of eucaryotic translation initiation factor 4B Ser422 is modulated by S6 kinases.". EMBO J. 23 (8): 1761-9. doi:10.1038/sj.emboj.7600193. PMID 15071500.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.