From Wikipedia, the free encyclopedia
| RprA RNA |
 |
| Type: |
Gene; sRNA; |
| 2° structure: |
Predicted; PFOLD; Moxon SJ |
| Seed alignment: |
Noncoding RNAs Database |
| Avg length: |
108.7 nucleotides |
| Avg identity: |
81% |
|
The RprA RNA gene encodes a 106 nucleotide regulatory non-coding RNA. Translational regulation of the stationary phase sigma factor RpoS is mediated by the formation of a double-stranded RNA stem-loop structure in the upstream region of the rpoS messenger RNA, occluding the translation initiation site. Clones carrying rprA (RpoS regulator RNA A) increased the translation of RpoS. As with DsrA, RprA is predicted to form three stem-loops. Thus, at least two small RNAs, DsrA and RprA, participate in the positive regulation of RpoS translation. RprA also appears to bind to the RpoS leader.[1] RprA is non-essential.[2] Wasserman et al. demonstrated that this RNA is bound by the Hfq protein.[3]
[edit] References
- ^ Majdalani, N; Hernandez D, Gottesman S (2002). "Regulation and mode of action of the second small RNA activator of RpoS translation, RprA". Mol Microbiol 46: 813–826. doi:10.1046/j.1365-2958.2002.03203.x. PMID 12410838.
- ^ Majdalani, N; Chen S, Murrow J, St John K, Gottesman S (2001). "Regulation of RpoS by a novel small RNA: the characterization of RprA". Mol Microbiol 39: 1382–1394. doi:10.1111/j.1365-2958.2001.02329.x. PMID 11251852.
- ^ Wassarman KM, Repoila F, Rosenow C, Storz G, Gottesman S (2001). "Identification of novel small RNAs using comparative genomics and microarrays". Genes Dev. 15 (13): 1637–51. doi:10.1101/gad.901001. PMID 11445539.
[edit] External links
