RPN2

From Wikipedia, the free encyclopedia

Ribophorin II

Identifiers

RPN2; RIBIIR; RPN-II; RPNII; SWP1

External IDs

OMIM: 180490 MGI: 98085 HomoloGene: 2214

Gene ontology
Molecular Function:	• dolichyl-diphosphooligosaccharide-protein glycotransferase activity • transferase activity
Cellular Component:	• endoplasmic reticulum • oligosaccharyl transferase complex • membrane • integral to membrane
Biological Process:	• protein modification process • protein amino acid N-linked glycosylation via asparagine

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_002951 (mRNA)
NP_002942 (protein)

XM_977943 (mRNA)
XP_983037 (protein)

Location

Chr 20: 35.24 - 35.3 Mb

Chr 2: 156.97 - 157.02 Mb

Pubmed search

[1]

[2]

Ribophorin II, also known as RPN2, is a human gene.^[1]

This gene encodes a type I integral membrane protein found only in the rough endoplasmic reticulum. The encoded protein is part of an N-oligosaccharyl transferase complex that links high mannose oligosaccharides to asparagine residues found in the Asn-X-Ser/Thr consensus motif of nascent polypeptide chains. This protein is similar in sequence to the yeast oligosaccharyl transferase subunit SWP1.^[1]

[edit] References

^ ^a ^b Entrez Gene: RPN2 ribophorin II.

[edit] Further reading

Stoffel M, Xiang K, Bell GI (1993). "Dinucleotide repeat polymorphism at the human ribophorin II locus (RPN2) on chromosome 20q.". Hum. Mol. Genet. 1 (8): 656. PMID 1301181.
Löffler C, Rao VV, Hansmann I (1991). "Mapping of the ribophorin II (RPN II) gene to human chromosome 20q12-q13.1 by in-situ hybridization.". Hum. Genet. 87 (2): 221–2. PMID 2066112.
Crimaudo C, Hortsch M, Gausepohl H, Meyer DI (1987). "Human ribophorins I and II: the primary structure and membrane topology of two highly conserved rough endoplasmic reticulum-specific glycoproteins.". EMBO J. 6 (1): 75–82. PMID 3034581.
Kumar V, Heinemann FS, Ozols J (1998). "Interleukin-2 induces N-glycosylation in T-cells: characterization of human lymphocyte oligosaccharyltransferase.". Biochem. Biophys. Res. Commun. 247 (2): 524–9. doi:10.1006/bbrc.1998.8780. PMID 9642163.
Fu J, Kreibich G (2000). "Retention of subunits of the oligosaccharyltransferase complex in the endoplasmic reticulum.". J. Biol. Chem. 275 (6): 3984–90. PMID 10660554.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801.
Kelleher DJ, Karaoglu D, Mandon EC, Gilmore R (2003). "Oligosaccharyltransferase isoforms that contain different catalytic STT3 subunits have distinct enzymatic properties.". Mol. Cell 12 (1): 101–11. PMID 12887896.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Shibatani T, David LL, McCormack AL, et al. (2005). "Proteomic analysis of mammalian oligosaccharyltransferase reveals multiple subcomplexes that contain Sec61, TRAP, and two potential new subunits.". Biochemistry 44 (16): 5982–92. doi:10.1021/bi047328f. PMID 15835887.
Tu LC, Yan X, Hood L, Lin B (2007). "Proteomics analysis of the interactome of N-myc downstream regulated gene 1 and its interactions with the androgen response program in prostate cancer cells.". Mol. Cell Proteomics 6 (4): 575–88. doi:10.1074/mcp.M600249-MCP200. PMID 17220478.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.