RPL29

From Wikipedia, the free encyclopedia

Ribosomal protein L29

Identifiers

RPL29; HIP; HUMRPL29; MGC88589

External IDs

OMIM: 601832 MGI: 3647233 HomoloGene: 87621

Gene ontology
Molecular Function:	• RNA binding • structural constituent of ribosome • heparin binding
Cellular Component:	• intracellular • ribosome • cytosolic large ribosomal subunit (sensu Eukaryota)
Biological Process:	• translation • embryo implantation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

NM_000992 (mRNA)
NP_000983 (protein)

XM_146296 (mRNA)
XP_146296 (protein)

Location

Chr 3: 52 - 52 Mb

Chr 8: 35.8 - 35.8 Mb

Pubmed search

[1]

[2]

Ribosomal protein L29, also known as RPL29, is a human gene.^[1]

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a cytoplasmic ribosomal protein that is a component of the 60S subunit. The protein belongs to the L29E family of ribosomal proteins. The protein is also a peripheral membrane protein expressed on the cell surface that directly binds heparin. Although this gene was previously reported to map to 3q29-qter, it is believed that it is located at 3p21.3-p21.2. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.^[1]

[edit] References

^ ^a ^b Entrez Gene: RPL29 ribosomal protein L29.

[edit] Further reading

Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins.". Biochem. Cell Biol. 73 (11-12): 933–47. PMID 8722009.
Nika H, Hultin T (1984). "Location of the sulfhydryl groups involved in disulfide interaction between the neighboring proteins L6 and L29 in mammalian ribosomes. S-cleavage of the cyanylated proteins in polyacrylamide gels after separation by dodecylsulfate gel electrophoresis.". Eur. J. Biochem. 142 (3): 521–6. PMID 6468376.
Law PT, Tsui SK, Lam WY, et al. (1996). "A novel cDNA encoding a human homologue of ribosomal protein L29.". Biochim. Biophys. Acta 1305 (3): 105–8. PMID 8597591.
Liu S, Smith SE, Julian J, et al. (1996). "cDNA cloning and expression of HIP, a novel cell surface heparan sulfate/heparin-binding protein of human uterine epithelial cells and cell lines.". J. Biol. Chem. 271 (20): 11817–23. PMID 8662616.
Rohde LH, Julian J, Babaknia A, Carson DD (1996). "Cell surface expression of HIP, a novel heparin/heparan sulfate binding protein, of human uterine epithelial cells and cell lines.". J. Biol. Chem. 271 (20): 11824–30. PMID 8662617.
Jacobs AL, Julian J, Sahin AA, Carson DD (1997). "Heparin/heparan sulfate interacting protein expression and functions in human breast cancer cells and normal breast epithelia.". Cancer Res. 57 (22): 5148–54. PMID 9371517.
Garcia-Barcelo M, Law PT, Tsui SK, et al. (1998). "Mapping of the human ribosomal large subunit protein gene RPL29 to human chromosome 3q29-qter.". Genomics 46 (1): 148–51. doi:10.1006/geno.1997.4990. PMID 9403071.
Koldamova RP, Lefterov IM, DiSabella MT, et al. (1999). "Human bleomycin hydrolase binds ribosomal proteins.". Biochemistry 38 (22): 7111–7. doi:10.1021/bi990135l. PMID 10353821.
Kudo H, Senju S, Mitsuya H, Nishimura Y (2000). "Mouse and human GTPBP2, newly identified members of the GP-1 family of GTPase.". Biochem. Biophys. Res. Commun. 272 (2): 456–65. doi:10.1006/bbrc.2000.2763. PMID 10833435.
Uechi T, Tanaka T, Kenmochi N (2001). "A complete map of the human ribosomal protein genes: assignment of 80 genes to the cytogenetic map and implications for human disorders.". Genomics 72 (3): 223–30. doi:10.1006/geno.2000.6470. PMID 11401437.
Kirn-Safran CB, Julian J, Fongemie JE, et al. (2002). "Changes in the cytologic distribution of heparin/heparan sulfate interacting protein/ribosomal protein L29 (HIP/RPL29) during in vivo and in vitro mouse mammary epithelial cell expression and differentiation.". Dev. Dyn. 223 (1): 70–84. doi:10.1002/dvdy.1226. PMID 11803571.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Hoke DE, Carson DD, Höök M (2006). "A heparin binding synthetic peptide from human HIP / RPL29 fails to specifically differentiate between anticoagulantly active and inactive species of heparin.". Journal of negative results in biomedicine 2: 1. PMID 12659638.
Odintsova TI, Müller EC, Ivanov AV, et al. (2004). "Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing.". J. Protein Chem. 22 (3): 249–58. PMID 12962325.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics.". Nature 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413.
Nakanishi K, Komatsu Y, Kogawa N, Matsushita H (2005). "Analysis of eluted peptides from type 1 diabetes-susceptible HLA class II molecules identified novel islet protein, heparin/heparan sulfate-interacting protein.". Biochem. Biophys. Res. Commun. 329 (1): 356–61. doi:10.1016/j.bbrc.2005.01.144. PMID 15721314.
Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome.". Cell 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
Liu JJ, Huang BH, Zhang J, et al. (2006). "Repression of HIP/RPL29 expression induces differentiation in colon cancer cells.". J. Cell. Physiol. 207 (2): 287–92. doi:10.1002/jcp.20589. PMID 16475173.