RPA1

From Wikipedia, the free encyclopedia

Replication protein A1, 70kDa

PDB rendering based on 1ewi.

Available structures: 1ewi, 1fgu, 1jmc, 1l1o, 2b29, 2b3g

Identifiers

Symbol(s)

RPA1; HSSB; REPA1; RF-A; RP-A; RPA70

External IDs

OMIM: 179835 MGI: 1915525 HomoloGene: 2208

Gene ontology
Molecular Function:	• DNA binding • chromatin binding • single-stranded DNA binding • protein binding • zinc ion binding • metal ion binding
Cellular Component:	• condensed chromosome • nucleus • DNA replication factor A complex
Biological Process:	• DNA-dependent DNA replication • DNA repair • DNA recombination • meiosis

Orthologs

Human

Mouse

Refseq

NM_002945 (mRNA)
NP_002936 (protein)

NM_026653 (mRNA)
NP_080929 (protein)

Location

Chr 17: 1.68 - 1.75 Mb

Chr 11: 75.12 - 75.16 Mb

Pubmed search

[1]

[2]

Replication protein A1, 70kDa, also known as RPA1, is a human gene.

[edit] Further reading

Iftode C, Daniely Y, Borowiec JA (1999). "Replication protein A (RPA): the eukaryotic SSB.". Crit. Rev. Biochem. Mol. Biol. 34 (3): 141–80. PMID 10473346.
Binz SK, Sheehan AM, Wold MS (2005). "Replication protein A phosphorylation and the cellular response to DNA damage.". DNA Repair (Amst.) 3 (8-9): 1015–24. doi:10.1016/j.dnarep.2004.03.028. PMID 15279788.
Dornreiter I, Erdile LF, Gilbert IU, et al. (1992). "Interaction of DNA polymerase alpha-primase with cellular replication protein A and SV40 T antigen.". EMBO J. 11 (2): 769–76. PMID 1311258.
Erdile LF, Heyer WD, Kolodner R, Kelly TJ (1991). "Characterization of a cDNA encoding the 70-kDa single-stranded DNA-binding subunit of human replication protein A and the role of the protein in DNA replication.". J. Biol. Chem. 266 (18): 12090–8. PMID 2050703.
Li L, Lu X, Peterson CA, Legerski RJ (1995). "An interaction between the DNA repair factor XPA and replication protein A appears essential for nucleotide excision repair.". Mol. Cell. Biol. 15 (10): 5396–402. PMID 7565690.
Keshav KF, Chen C, Dutta A (1995). "Rpa4, a homolog of the 34-kilodalton subunit of the replication protein A complex.". Mol. Cell. Biol. 15 (6): 3119–28. PMID 7760808.
Umbricht CB, Griffin CA, Hawkins AL, et al. (1994). "High-resolution genomic mapping of the three human replication protein A genes (RPA1, RPA2, and RPA3).". Genomics 20 (2): 249–57. doi:10.1006/geno.1994.1161. PMID 8020972.
Umbricht CB, Erdile LF, Jabs EW, Kelly TJ (1993). "Cloning, overexpression, and genomic mapping of the 14-kDa subunit of human replication protein A.". J. Biol. Chem. 268 (9): 6131–8. PMID 8454588.
Gomes XV, Wold MS (1996). "Functional domains of the 70-kilodalton subunit of human replication protein A.". Biochemistry 35 (32): 10558–68. doi:10.1021/bi9607517. PMID 8756712.
Bochkarev A, Pfuetzner RA, Edwards AM, Frappier L (1997). "Structure of the single-stranded-DNA-binding domain of replication protein A bound to DNA.". Nature 385 (6612): 176–81. doi:10.1038/385176a0. PMID 8990123.
Amacker M, Hottiger M, Mossi R, Hübscher U (1997). "HIV-1 nucleocapsid protein and replication protein A influence the strand displacement DNA synthesis of lentiviral reverse transcriptase.". AIDS 11 (4): 534–6. PMID 9084803.
Cujec TP, Cho H, Maldonado E, et al. (1997). "The human immunodeficiency virus transactivator Tat interacts with the RNA polymerase II holoenzyme.". Mol. Cell. Biol. 17 (4): 1817–23. PMID 9121429.
Loor G, Zhang SJ, Zhang P, et al. (1998). "Identification of DNA replication and cell cycle proteins that interact with PCNA.". Nucleic Acids Res. 25 (24): 5041–6. PMID 9396813.
Bochkareva E, Frappier L, Edwards AM, Bochkarev A (1998). "The RPA32 subunit of human replication protein A contains a single-stranded DNA-binding domain.". J. Biol. Chem. 273 (7): 3932–6. PMID 9461578.
Golub EI, Gupta RC, Haaf T, et al. (1999). "Interaction of human rad51 recombination protein with single-stranded DNA binding protein, RPA.". Nucleic Acids Res. 26 (23): 5388–93. PMID 9826763.
Shao RG, Cao CX, Zhang H, et al. (1999). "Replication-mediated DNA damage by camptothecin induces phosphorylation of RPA by DNA-dependent protein kinase and dissociates RPA:DNA-PK complexes.". EMBO J. 18 (5): 1397–406. doi:10.1093/emboj/18.5.1397. PMID 10064605.
Brosh RM, Orren DK, Nehlin JO, et al. (1999). "Functional and physical interaction between WRN helicase and human replication protein A.". J. Biol. Chem. 274 (26): 18341–50. PMID 10373438.
Kim ST, Lim DS, Canman CE, Kastan MB (2000). "Substrate specificities and identification of putative substrates of ATM kinase family members.". J. Biol. Chem. 274 (53): 37538–43. PMID 10608806.
Brosh RM, Li JL, Kenny MK, et al. (2000). "Replication protein A physically interacts with the Bloom's syndrome protein and stimulates its helicase activity.". J. Biol. Chem. 275 (31): 23500–8. doi:10.1074/jbc.M001557200. PMID 10825162.