RNH1

From Wikipedia, the free encyclopedia

Ribonuclease/angiogenin inhibitor 1

PDB rendering based on 1a4y.

Available structures: 1a4y, 1z7x, 2bex

Identifiers

Symbol(s)

RNH1; MGC18200; MGC4569; MGC54054; RAI; RNH

External IDs

OMIM: 173320 MGI: 1195456 HomoloGene: 2204

Gene ontology
Molecular Function:	• protein binding • ribonuclease inhibitor activity
Cellular Component:	• angiogenin-PRI complex
Biological Process:	• mRNA catabolic process • regulation of angiogenesis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_002939 (mRNA)
NP_002930 (protein)

NM_145135 (mRNA)
NP_660117 (protein)

Location

Chr 11: 0.48 - 0.5 Mb

Chr 7: 141.01 - 141.02 Mb

Pubmed search

[1]

[2]

Ribonuclease/angiogenin inhibitor 1, also known as RNH1, is a human gene.^[1]

[edit] References

^ Entrez Gene: RNH1 ribonuclease/angiogenin inhibitor 1.

[edit] Further reading

Zneimer SM, Crawford D, Schneider NR, Beutler B (1991). "Mapping of the human ribonuclease inhibitor gene (RNH) to chromosome 11p15 by in situ hybridization.". Genomics 8 (1): 175–8. PMID 2081593.
Weremowicz S, Fox EA, Morton CC, Vallee BL (1991). "The placental ribonuclease inhibitor (RNH) gene is located on chromosome subband 11p15.5.". Genomics 8 (4): 717–21. PMID 2276743.
Lee FS, Vallee BL (1989). "Binding of placental ribonuclease inhibitor to the active site of angiogenin.". Biochemistry 28 (8): 3556–61. PMID 2742853.
Bond MD, Vallee BL (1989). "Isolation of bovine angiogenin using a placental ribonuclease inhibitor binding assay.". Biochemistry 27 (17): 6282–7. PMID 3064806.
Hofsteenge J, Kieffer B, Matthies R, et al. (1989). "Amino acid sequence of the ribonuclease inhibitor from porcine liver reveals the presence of leucine-rich repeats.". Biochemistry 27 (23): 8537–44. PMID 3219361.
Lee FS, Fox EA, Zhou HM, et al. (1989). "Primary structure of human placental ribonuclease inhibitor.". Biochemistry 27 (23): 8545–53. PMID 3219362.
Schneider R, Schneider-Scherzer E, Thurnher M, et al. (1989). "The primary structure of human ribonuclease/angiogenin inhibitor (RAI) discloses a novel highly diversified protein superfamily with a common repetitive module.". EMBO J. 7 (13): 4151–6. PMID 3243277.
Shapiro R, Vallee BL (1987). "Human placental ribonuclease inhibitor abolishes both angiogenic and ribonucleolytic activities of angiogenin.". Proc. Natl. Acad. Sci. U.S.A. 84 (8): 2238–41. PMID 3470787.
Kiyohara H, Menjo M (1984). "Ribonuclease and ribonuclease inhibitor in the human pancreas.". Gastroenterol. Jpn. 18 (5): 468–73. PMID 6653993.
Nadano D, Yasuda T, Takeshita H, et al. (1994). "Purification and characterization of human brain ribonuclease inhibitor.". Arch. Biochem. Biophys. 312 (2): 421–8. doi:10.1006/abbi.1994.1328. PMID 8037455.
Kobe B, Deisenhofer J (1994). "Crystal structure of porcine ribonuclease inhibitor, a protein with leucine-rich repeats.". Nature 366 (6457): 751–6. doi:10.1038/366751a08107760. PMID 8264799.
Papageorgiou AC, Shapiro R, Acharya KR (1997). "Molecular recognition of human angiogenin by placental ribonuclease inhibitor--an X-ray crystallographic study at 2.0 A resolution.". EMBO J. 16 (17): 5162–77. doi:10.1093/emboj/16.17.5162. PMID 9311977.
Gaur D, Swaminathan S, Batra JK (2001). "Interaction of human pancreatic ribonuclease with human ribonuclease inhibitor. Generation of inhibitor-resistant cytotoxic variants.". J. Biol. Chem. 276 (27): 24978–84. doi:10.1074/jbc.M102440200. PMID 11342552.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Fu P, Chen J, Tian Y, et al. (2005). "Anti-tumor effect of hematopoietic cells carrying the gene of ribonuclease inhibitor.". Cancer Gene Ther. 12 (3): 268–75. doi:10.1038/sj.cgt.7700742. PMID 15592448.
Iyer S, Holloway DE, Kumar K, et al. (2005). "Molecular recognition of human eosinophil-derived neurotoxin (RNase 2) by placental ribonuclease inhibitor.". J. Mol. Biol. 347 (3): 637–55. doi:10.1016/j.jmb.2005.01.035. PMID 15755456.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Johnson RJ, McCoy JG, Bingman CA, et al. (2007). "Inhibition of human pancreatic ribonuclease by the human ribonuclease inhibitor protein.". J. Mol. Biol. 368 (2): 434–49. doi:10.1016/j.jmb.2007.02.005. PMID 17350650.