RNGTT

From Wikipedia, the free encyclopedia

RNA guanylyltransferase and 5'-phosphatase

PDB rendering based on 1i9s.

Available structures: 1i9s, 1i9t, 2c46

Identifiers

Symbol(s)

RNGTT; CAP1A; DKFZp686J2031; HCE; HCE1; hCAP

External IDs

OMIM: 603512 MGI: 1329041 HomoloGene: 37851

Gene ontology
Molecular Function:	• mRNA guanylyltransferase activity • polynucleotide 5'-phosphatase activity • protein tyrosine/serine/threonine phosphatase activity • transferase activity • nucleotidyltransferase activity • hydrolase activity
Cellular Component:	• nucleus
Biological Process:	• mRNA capping • protein amino acid dephosphorylation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_003800 (mRNA)
NP_003791 (protein)

NM_011884 (mRNA)
NP_036014 (protein)

Location

Chr 6: 89.38 - 89.73 Mb

Chr 4: 33.64 - 33.83 Mb

Pubmed search

[1]

[2]

RNA guanylyltransferase and 5'-phosphatase, also known as RNGTT, is a human gene.^[1]

[edit] References

^ Entrez Gene: RNGTT RNA guanylyltransferase and 5'-phosphatase.

[edit] Further reading

Yue Z, Maldonado E, Pillutla R, et al. (1998). "Mammalian capping enzyme complements mutant Saccharomyces cerevisiae lacking mRNA guanylyltransferase and selectively binds the elongating form of RNA polymerase II.". Proc. Natl. Acad. Sci. U.S.A. 94 (24): 12898–903. PMID 9371772.
Tsukamoto T, Shibagaki Y, Murakoshi T, et al. (1998). "Cloning and characterization of two human cDNAs encoding the mRNA capping enzyme.". Biochem. Biophys. Res. Commun. 243 (1): 101–8. doi:10.1006/bbrc.1997.8038. PMID 9473487.
Yamada-Okabe T, Doi R, Shimmi O, et al. (1998). "Isolation and characterization of a human cDNA for mRNA 5'-capping enzyme.". Nucleic Acids Res. 26 (7): 1700–6. PMID 9512541.
Pillutla RC, Yue Z, Maldonado E, Shatkin AJ (1998). "Recombinant human mRNA cap methyltransferase binds capping enzyme/RNA polymerase IIo complexes.". J. Biol. Chem. 273 (34): 21443–6. PMID 9705270.
Pillutla RC, Shimamoto A, Furuichi Y, Shatkin AJ (1999). "Human mRNA capping enzyme (RNGTT) and cap methyltransferase (RNMT) map to 6q16 and 18p11.22-p11.23, respectively.". Genomics 54 (2): 351–3. doi:10.1006/geno.1998.5604. PMID 9828141.
Wen Y, Shatkin AJ (1999). "Transcription elongation factor hSPT5 stimulates mRNA capping.". Genes Dev. 13 (14): 1774–9. PMID 10421630.
Chiu YL, Coronel E, Ho CK, et al. (2001). "HIV-1 Tat protein interacts with mammalian capping enzyme and stimulates capping of TAR RNA.". J. Biol. Chem. 276 (16): 12959–66. doi:10.1074/jbc.M007901200. PMID 11278368.
Chiu YL, Ho CK, Saha N, et al. (2002). "Tat stimulates cotranscriptional capping of HIV mRNA.". Mol. Cell 10 (3): 585–97. PMID 12408826.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Zhou M, Deng L, Kashanchi F, et al. (2004). "The Tat/TAR-dependent phosphorylation of RNA polymerase II C-terminal domain stimulates cotranscriptional capping of HIV-1 mRNA.". Proc. Natl. Acad. Sci. U.S.A. 100 (22): 12666–71. doi:10.1073/pnas.1835726100. PMID 14569024.
Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMID 15342556.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.