RNF34

From Wikipedia, the free encyclopedia

Ring finger protein 34

Identifiers

RNF34; RIF; FLJ21786; RFI; RIFF

External IDs

OMIM: 608299 MGI: 2153340 HomoloGene: 11839

Gene ontology
Molecular Function:	• protein binding • zinc ion binding • ligase activity • metal ion binding
Cellular Component:	• nucleus • membrane
Biological Process:	• ubiquitin cycle • apoptosis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_025126 (mRNA)
NP_079402 (protein)

NM_030564 (mRNA)
NP_085041 (protein)

Location

Chr 12: 120.32 - 120.35 Mb

Chr 5: 123.11 - 123.13 Mb

Pubmed search

[1]

[2]

Ring finger protein 34, also known as RNF34, is a human gene.^[1]

The protein encoded by this gene contains a RINF finger, a motif known to be involved in protein-protein and protein-DNA interactions. This protein interacts with DNAJA3/hTid-1, which is a DnaJ protein reported to function as a modulator of apoptosis. Overexpression of this gene in Hela cells was shown to confer the resistance to TNF-alpha induced apoptosis, suggesting an anti-apoptotic function of this protein. This protein can be cleaved by caspase-3 during the induction of apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been reported.^[1]

[edit] References

^ ^a ^b Entrez Gene: RNF34 ring finger protein 34.

[edit] Further reading

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149.
Sasaki S, Nakamura T, Arakawa H, et al. (2002). "Isolation and characterization of a novel gene, hRFI, preferentially expressed in esophageal cancer.". Oncogene 21 (32): 5024–30. doi:10.1038/sj.onc.1205627. PMID 12118383.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
McDonald ER, El-Deiry WS (2004). "Suppression of caspase-8- and -10-associated RING proteins results in sensitization to death ligands and inhibition of tumor cell growth.". Proc. Natl. Acad. Sci. U.S.A. 101 (16): 6170–5. doi:10.1073/pnas.0307459101. PMID 15069192.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Sasaki S, Watanabe T, Konishi T, et al. (2005). "Effects of expression of hRFI on adenoma formation and tumor progression in colorectal adenoma-carcinoma sequence.". J. Exp. Clin. Cancer Res. 23 (3): 507–12. PMID 15595643.
Konishi T, Sasaki S, Watanabe T, et al. (2005). "Overexpression of hRFI (human ring finger homologous to inhibitor of apoptosis protein type) inhibits death receptor-mediated apoptosis in colorectal cancer cells.". Mol. Cancer Ther. 4 (5): 743–50. doi:10.1158/1535-7163.MCT-05-0020. PMID 15897238.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.