RNF12

From Wikipedia, the free encyclopedia

Ring finger protein 12

Identifiers

RNF12; MGC15161; NY-REN-43; RLIM

External IDs

OMIM: 300379 MGI: 1342291 HomoloGene: 7920

Gene ontology
Molecular Function:	• transcription corepressor activity • ubiquitin-protein ligase activity • protein binding • zinc ion binding • metal ion binding
Cellular Component:	• transcriptional repressor complex
Biological Process:	• transcription • regulation of transcription, DNA-dependent • ubiquitin cycle • negative regulation of transcription

Orthologs

Human

Mouse

Refseq

NM_016120 (mRNA)
NP_057204 (protein)

NM_011276 (mRNA)
NP_035406 (protein)

Location

Chr X: 73.72 - 73.75 Mb

Chr X: 100.16 - 100.18 Mb

Pubmed search

[1]

[2]

Ring finger protein 12, also known as RNF12, is a human gene.^[1]

The protein encoded by this gene is a RING-H2 zinc finger protein. It has been shown to be a ubiquitin protein ligase that targets LIM domain binding 1 (LDB1/CLIM), and causes proteasome-dependent degradation of LDB1. This protein and LDB1 are co-repressors of LHX1/LIM-1, a homeodomain transcription factor. Alternatively spliced transcript variants encoding the same protein have been reported.^[1]

[edit] References

^ ^a ^b Entrez Gene: RNF12 ring finger protein 12.

[edit] Further reading

Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Hiratani I, Yamamoto N, Mochizuki T, et al. (2003). "Selective degradation of excess Ldb1 by Rnf12/RLIM confers proper Ldb1 expression levels and Xlim-1/Ldb1 stoichiometry in Xenopus organizer functions.". Development 130 (17): 4161-75. PMID 12874135.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Ostendorff HP, Peirano RI, Peters MA, et al. (2002). "Ubiquitination-dependent cofactor exchange on LIM homeodomain transcription factors.". Nature 416 (6876): 99-103. doi:10.1038/416099a. PMID 11882901.
Ostendorff HP, Bossenz M, Mincheva A, et al. (2001). "Functional characterization of the gene encoding RLIM, the corepressor of LIM homeodomain factors.". Genomics 69 (1): 120-30. doi:10.1006/geno.2000.6311. PMID 11013082.
Scanlan MJ, Gordan JD, Williamson B, et al. (1999). "Antigens recognized by autologous antibody in patients with renal-cell carcinoma.". Int. J. Cancer 83 (4): 456-64. PMID 10508479.
Bach I, Rodriguez-Esteban C, Carrière C, et al. (1999). "RLIM inhibits functional activity of LIM homeodomain transcription factors via recruitment of the histone deacetylase complex.". Nat. Genet. 22 (4): 394-9. doi:10.1038/11970. PMID 10431247.