RNF11

From Wikipedia, the free encyclopedia

Ring finger protein 11

Identifiers

RNF11; CGI-123; MGC51169; SID1669

External IDs

Gene ontology
Molecular Function:	• DNA binding • protein binding • zinc ion binding • metal ion binding
Cellular Component:	• ubiquitin ligase complex
Biological Process:	• protein ubiquitination during ubiquitin-dependent protein catabolic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_014372 (mRNA)
NP_055187 (protein)

NM_013876 (mRNA)
NP_038904 (protein)

Location

Chr 1: 51.47 - 51.51 Mb

Chr 4: 108.95 - 108.97 Mb

Pubmed search

[1]

[2]

Ring finger protein 11, also known as RNF11, is a human gene.^[1]

The protein encoded by this gene contains a RING-H2 finger motif, which is known to be important for protein-protein interactions. The expression of this gene has been shown to be induced by mutant RET proteins (MEN2A/MEN2B). The germline mutations in RET gene are known to be responsible for the development of multiple endocrine neoplasia (MEN).^[1]

1 See also
2 References
3 Further reading
4 External links

[edit] See also

RING finger domain

[edit] References

^ ^a ^b Entrez Gene: RNF11 ring finger protein 11.

[edit] Further reading

Burger A, Amemiya Y, Kitching R, Seth AK (2006). "Novel RING E3 ubiquitin ligases in breast cancer.". Neoplasia 8 (8): 689–95. doi:10.1593/neo.06469. PMID 16925951.
Seki N, Hattori A, Hayashi A, et al. (2000). "Cloning and expression profile of mouse and human genes, Rnf11/RNF11, encoding a novel RING-H2 finger protein.". Biochim. Biophys. Acta 1489 (2-3): 421–7. PMID 10673045.
Lai CH, Chou CY, Ch'ang LY, et al. (2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.". Genome Res. 10 (5): 703–13. PMID 10810093.
Jolliffe CN, Harvey KF, Haines BP, et al. (2001). "Identification of multiple proteins expressed in murine embryos as binding partners for the WW domains of the ubiquitin-protein ligase Nedd4.". Biochem. J. 351 Pt 3: 557–65. PMID 11042109.
Watanabe T, Ichihara M, Hashimoto M, et al. (2002). "Characterization of gene expression induced by RET with MEN2A or MEN2B mutation.". Am. J. Pathol. 161 (1): 249–56. PMID 12107109.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Kitching R, Wong MJ, Koehler D, et al. (2003). "The RING-H2 protein RNF11 is differentially expressed in breast tumours and interacts with HECT-type E3 ligases.". Biochim. Biophys. Acta 1639 (2): 104–12. PMID 14559117.
Subramaniam V, Li H, Wong M, et al. (2003). "The RING-H2 protein RNF11 is overexpressed in breast cancer and is a target of Smurf2 E3 ligase.". Br. J. Cancer 89 (8): 1538–44. doi:10.1038/sj.bjc.6601301. PMID 14562029.
Li H, Seth A (2004). "An RNF11: Smurf2 complex mediates ubiquitination of the AMSH protein.". Oncogene 23 (10): 1801–8. doi:10.1038/sj.onc.1207319. PMID 14755250.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway.". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMID 15231748.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Connor MK, Azmi PB, Subramaniam V, et al. (2005). "Molecular characterization of ring finger protein 11.". Mol. Cancer Res. 3 (8): 453–61. doi:10.1158/1541-7786.MCR-04-0166. PMID 16123141.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.
Anderson LR, Betarbet R, Gearing M, et al. (2007). "PARK10 candidate RNF11 is expressed by vulnerable neurons and localizes to Lewy bodies in Parkinson disease brain.". J. Neuropathol. Exp. Neurol. 66 (10): 955–64. doi:10.1097/nen.0b013e3181567f17. PMID 17917589.