RNA integrity number
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The RNA integrity number (RIN) is an algorithm for assigning integrity values to RNA measurements.
The integrity of RNA is a major concern for gene expression studies and traditionally has been evaluated using the 28S to 18S rRNA ratio, a method that has been shown to be inconsistent. The RIN algorithm was devised to overcome this issue. The RIN algorithm is applied to electrophoretic RNA measurements and based on a combination of different features that contribute information about the RNA integrity to provide a more robust universal measure.
[edit] External links
- RIN information from Agilent Technologies
- RIN article in BMC Molecular Biology
- RIN page from quantiom bioinformatics
- More info here => http://RNA-integrity.gene-quantification.info
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