RNASET2

From Wikipedia, the free encyclopedia

Ribonuclease T2

Identifiers

RNASET2; RNASE6PL; bA514O12.3

External IDs

MGI: 1915445 HomoloGene: 31190

Gene ontology
Molecular Function:	• RNA binding • endoribonuclease activity • hydrolase activity
Cellular Component:	• extracellular region
Biological Process:	• RNA catabolic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_003730 (mRNA)
NP_003721 (protein)

XM_001004886 (mRNA)
XP_001004886 (protein)

Location

Chr 6: 167.26 - 167.29 Mb

Chr 17: 7.95 - 7.99 Mb

Pubmed search

[1]

[2]

Ribonuclease T2, also known as RNASET2, is a human gene.^[1]

This ribonuclease gene is a novel member of the Rh/T2/S-glycoprotein class of extracellular ribonucleases. It is a single copy gene that maps to 6q27, a region associated with human malignancies and chromosomal rearrangement.^[1]

[edit] References

^ ^a ^b Entrez Gene: RNASET2 ribonuclease T2.

[edit] Further reading

Trubia M, Sessa L, Taramelli R (1997). "Mammalian Rh/T2/S-glycoprotein ribonuclease family genes: cloning of a human member located in a region of chromosome 6 (6q27) frequently deleted in human malignancies.". Genomics 42 (2): 342–4. doi:10.1006/geno.1997.4679. PMID 9192857.
Acquati F, Morelli C, Cinquetti R, et al. (2001). "Cloning and characterization of a senescence inducing and class II tumor suppressor gene in ovarian carcinoma at chromosome region 6q27.". Oncogene 20 (8): 980–8. doi:10.1038/sj.onc.1204178. PMID 11314033.
Liu Y, Emilion G, Mungall AJ, et al. (2002). "Physical and transcript map of the region between D6S264 and D6S149 on chromosome 6q27, the minimal region of allele loss in sporadic epithelial ovarian cancer.". Oncogene 21 (3): 387–99. doi:10.1038/sj.onc.1205067. PMID 11821951.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Acquati F, Possati L, Ferrante L, et al. (2005). "Tumor and metastasis suppression by the human RNASET2 gene.". Int. J. Oncol. 26 (5): 1159–68. PMID 15809705.
Campomenosi P, Salis S, Lindqvist C, et al. (2006). "Characterization of RNASET2, the first human member of the Rh/T2/S family of glycoproteins.". Arch. Biochem. Biophys. 449 (1-2): 17–26. doi:10.1016/j.abb.2006.02.022. PMID 16620762.