RNASEN

From Wikipedia, the free encyclopedia

Ribonuclease III, nuclear

Identifiers

RNASEN; DROSHA; Etohi2; HSA242976; RANSE3L; RN3; RNASE3L

External IDs

OMIM: 608828 MGI: 1261425 HomoloGene: 8293

Gene ontology
Molecular Function:	• double-stranded RNA binding • endonuclease activity • ribonuclease III activity • protein binding • hydrolase activity
Cellular Component:	• intracellular • nucleus
Biological Process:	• RNA processing

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

NM_013235 (mRNA)
NP_037367 (protein)

XM_906810 (mRNA)
XP_911903 (protein)

Location

Chr 5: 31.44 - 31.56 Mb

Chr 15: 12.77 - 12.88 Mb

Pubmed search

[1]

[2]

Ribonuclease III, nuclear, also known as RNASEN, is a human gene.^[1]

Members of the ribonuclease III superfamily of double-stranded (ds) RNA-specific endoribonucleases participate in diverse RNA maturation and decay pathways in eukaryotic and prokaryotic cells (Fortin et al., 2002). The RNase III Drosha is the core nuclease that executes the initiation step of microRNA (miRNA) processing in the nucleus (Lee et al., 2003).[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: RNASEN ribonuclease III, nuclear.

[edit] Further reading

Filippov V, Solovyev V, Filippova M, Gill SS (2000). "A novel type of RNase III family proteins in eukaryotes.". Gene 245 (1): 213–21. PMID 10713462.
Wu H, Xu H, Miraglia LJ, Crooke ST (2001). "Human RNase III is a 160-kDa protein involved in preribosomal RNA processing.". J. Biol. Chem. 275 (47): 36957–65. doi:10.1074/jbc.M005494200. PMID 10948199.
Gunther M, Laithier M, Brison O (2000). "A set of proteins interacting with transcription factor Sp1 identified in a two-hybrid screening.". Mol. Cell. Biochem. 210 (1-2): 131–42. PMID 10976766.
Fortin KR, Nicholson RH, Nicholson AW (2003). "Mouse ribonuclease III. cDNA structure, expression analysis, and chromosomal location.". BMC Genomics 3 (1): 26. PMID 12191433.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Lee Y, Ahn C, Han J, et al. (2003). "The nuclear RNase III Drosha initiates microRNA processing.". Nature 425 (6956): 415–9. doi:10.1038/nature01957. PMID 14508493.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Gregory RI, Yan KP, Amuthan G, et al. (2004). "The Microprocessor complex mediates the genesis of microRNAs.". Nature 432 (7014): 235–40. doi:10.1038/nature03120. PMID 15531877.
Zeng Y, Yi R, Cullen BR (2005). "Recognition and cleavage of primary microRNA precursors by the nuclear processing enzyme Drosha.". EMBO J. 24 (1): 138–48. doi:10.1038/sj.emboj.7600491. PMID 15565168.
Han J, Lee Y, Yeom KH, et al. (2005). "The Drosha-DGCR8 complex in primary microRNA processing.". Genes Dev. 18 (24): 3016–27. doi:10.1101/gad.1262504. PMID 15574589.
Landthaler M, Yalcin A, Tuschl T (2005). "The human DiGeorge syndrome critical region gene 8 and Its D. melanogaster homolog are required for miRNA biogenesis.". Curr. Biol. 14 (23): 2162–7. doi:10.1016/j.cub.2004.11.001. PMID 15589161.
Zeng Y, Cullen BR (2005). "Efficient processing of primary microRNA hairpins by Drosha requires flanking nonstructured RNA sequences.". J. Biol. Chem. 280 (30): 27595–603. doi:10.1074/jbc.M504714200. PMID 15932881.
Irvin-Wilson CV, Chaudhuri G (2006). "Alternative initiation and splicing in dicer gene expression in human breast cells.". Breast Cancer Res. 7 (4): R563–9. doi:10.1186/bcr1043. PMID 15987463.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Sugito N, Ishiguro H, Kuwabara Y, et al. (2007). "RNASEN regulates cell proliferation and affects survival in esophageal cancer patients.". Clin. Cancer Res. 12 (24): 7322–8. doi:10.1158/1078-0432.CCR-06-0515. PMID 17121874.
Kim YK, Kim VN (2007). "Processing of intronic microRNAs.". EMBO J. 26 (3): 775–83. doi:10.1038/sj.emboj.7601512. PMID 17255951.
Xing L, Kieff E (2007). "Epstein-Barr virus BHRF1 micro- and stable RNAs during latency III and after induction of replication.". J. Virol. 81 (18): 9967–75. doi:10.1128/JVI.02244-06. PMID 17626073.