RNA-3'-phosphate cyclase

From Wikipedia, the free encyclopedia

In enzymology, a RNA-3'-phosphate cyclase (EC 6.5.1.4) is an enzyme that catalyzes the chemical reaction

ATP + RNA 3'-terminal-phosphate $\rightleftharpoons$ AMP + diphosphate + RNA terminal-2',3'-cyclic-phosphate

Thus, the two substrates of this enzyme are ATP and RNA 3'-terminal-phosphate, whereas its 3 products are AMP, diphosphate, and RNA terminal-2',3'-cyclic-phosphate.

This enzyme belongs to the family of ligases, specifically those forming phosphoric-ester bonds. The systematic name of this enzyme class is RNA-3'-phosphate:RNA ligase (cyclizing, AMP-forming). This enzyme is also called RNA cyclase.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1QMH and 1QMI.

[edit] References

IUBMB entry for 6.5.1.4
BRENDA references for 6.5.1.4 (Recommended.)
PubMed references for 6.5.1.4
PubMed Central references for 6.5.1.4
Google Scholar references for 6.5.1.4
Filipowicz W, Konarska M, Gross HJ, Shatkin AJ (1983). "RNA 3'-terminal phosphate cyclase activity and RNA ligation in HeLa cell extract". Nucleic. Acids. Res. 11: 1405–18. doi:10.1093/nar/11.5.1405. PMID 6828385.
Reinberg D, Arenas J, Hurwitz J (1985). "The enzymatic conversion of 3'-phosphate terminated RNA chains to 2',3'-cyclic phosphate derivatives". J. Biol. Chem. 260: 6088–97. PMID 2581947.