RIN1

From Wikipedia, the free encyclopedia

Ras and Rab interactor 1

Identifiers

External IDs

OMIM: 605965 MGI: 2385695 HomoloGene: 3170

Gene ontology
Molecular Function:	• GTPase activator activity • protein binding
Cellular Component:	• cytoskeleton • plasma membrane
Biological Process:	• endocytosis • signal transduction • intracellular signaling cascade

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004292 (mRNA)
NP_004283 (protein)

NM_145495 (mRNA)
NP_663470 (protein)

Location

Chr 11: 65.86 - 65.86 Mb

Chr 19: 5.05 - 5.06 Mb

Pubmed search

[1]

[2]

Ras and Rab interactor 1, also known as RIN1, is a human gene.^[1]

[edit] References

^ Entrez Gene: RIN1 Ras and Rab interactor 1.

[edit] Further reading

Colicelli J, Nicolette C, Birchmeier C, et al. (1991). "Expression of three mammalian cDNAs that interfere with RAS function in Saccharomyces cerevisiae.". Proc. Natl. Acad. Sci. U.S.A. 88 (7): 2913–7. PMID 1849280.
Trowbridge IS, Lesley J, Trotter J, Hyman R (1985). "Thymocyte subpopulation enriched for progenitors with an unrearranged T-cell receptor beta-chain gene.". Nature 315 (6021): 666–9. PMID 3874369.
Han L, Colicelli J (1995). "A human protein selected for interference with Ras function interacts directly with Ras and competes with Raf1.". Mol. Cell. Biol. 15 (3): 1318–23. PMID 7862125.
Han L, Wong D, Dhaka A, et al. (1997). "Protein binding and signaling properties of RIN1 suggest a unique effector function.". Proc. Natl. Acad. Sci. U.S.A. 94 (10): 4954–9. PMID 9144171.
Afar DE, Han L, McLaughlin J, et al. (1997). "Regulation of the oncogenic activity of BCR-ABL by a tightly bound substrate protein RIN1.". Immunity 6 (6): 773–82. PMID 9208849.
Tall GG, Barbieri MA, Stahl PD, Horazdovsky BF (2001). "Ras-activated endocytosis is mediated by the Rab5 guanine nucleotide exchange activity of RIN1.". Dev. Cell 1 (1): 73–82. PMID 11703925.
Wang Y, Waldron RT, Dhaka A, et al. (2002). "The RAS effector RIN1 directly competes with RAF and is regulated by 14-3-3 proteins.". Mol. Cell. Biol. 22 (3): 916–26. PMID 11784866.
Murphy GA, Graham SM, Morita S, et al. (2002). "Involvement of phosphatidylinositol 3-kinase, but not RalGDS, in TC21/R-Ras2-mediated transformation.". J. Biol. Chem. 277 (12): 9966–75. doi:10.1074/jbc.M109059200. PMID 11788587.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Mitin NY, Ramocki MB, Zullo AJ, et al. (2004). "Identification and characterization of rain, a novel Ras-interacting protein with a unique subcellular localization.". J. Biol. Chem. 279 (21): 22353–61. doi:10.1074/jbc.M312867200. PMID 15031288.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Hu H, Bliss JM, Wang Y, Colicelli J (2005). "RIN1 is an ABL tyrosine kinase activator and a regulator of epithelial-cell adhesion and migration.". Curr. Biol. 15 (9): 815–23. doi:10.1016/j.cub.2005.03.049. PMID 15886098.
Zhang Y, Wolf-Yadlin A, Ross PL, et al. (2005). "Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules.". Mol. Cell Proteomics 4 (9): 1240–50. doi:10.1074/mcp.M500089-MCP200. PMID 15951569.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Hunker CM, Giambini H, Galvis A, et al. (2006). "Rin1 regulates insulin receptor signal transduction pathways.". Exp. Cell Res. 312 (7): 1106–18. doi:10.1016/j.yexcr.2005.12.021. PMID 16457816.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization.". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
Senda K, Goi T, Hirono Y, et al. (2007). "Analysis of RIN1 gene expression in colorectal cancer.". Oncol. Rep. 17 (5): 1171–5. PMID 17390061.
Kong C, Su X, Chen PI, Stahl PD (2007). "Rin1 interacts with signal-transducing adaptor molecule (STAM) and mediates epidermal growth factor receptor trafficking and degradation.". J. Biol. Chem. 282 (20): 15294–301. doi:10.1074/jbc.M611538200. PMID 17403676.