RILP (gene)

From Wikipedia, the free encyclopedia

Rab interacting lysosomal protein

PDB rendering based on 1yhn.

Available structures: 1yhn

Identifiers

Symbol(s)

RILP; FLJ31193; PP10141

External IDs

OMIM: 607848 MGI: 2144271 HomoloGene: 19596

Gene ontology
Molecular Function:	• Rab GTPase binding
Cellular Component:	• lysosomal membrane • late endosome
Biological Process:	• protein transport

Orthologs

Human

Mouse

Refseq

NM_031430 (mRNA)
NP_113618 (protein)

NM_001029938 (mRNA)
NP_001025109 (protein)

Location

Chr 17: 1.5 - 1.5 Mb

Chr 11: 75.33 - 75.33 Mb

Pubmed search

[1]

[2]

Rab interacting lysosomal protein, also known as RILP, is a human gene.^[1]

RILP, along with the GTPase RAB7 (MIM 602298), controls late endocytic transport.[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: RILP Rab interacting lysosomal protein.

[edit] Further reading

Cantalupo G, Alifano P, Roberti V, et al. (2001). "Rab-interacting lysosomal protein (RILP): the Rab7 effector required for transport to lysosomes.". EMBO J. 20 (4): 683-93. doi:10.1093/emboj/20.4.683. PMID 11179213.
Bucci C, De Gregorio L, Bruni CB (2001). "Expression analysis and chromosomal assignment of PRA1 and RILP genes.". Biochem. Biophys. Res. Commun. 286 (4): 815-9. doi:10.1006/bbrc.2001.5466. PMID 11520070.
Jordens I, Fernandez-Borja M, Marsman M, et al. (2002). "The Rab7 effector protein RILP controls lysosomal transport by inducing the recruitment of dynein-dynactin motors.". Curr. Biol. 11 (21): 1680-5. PMID 11696325.
Wang T, Hong W (2003). "Interorganellar regulation of lysosome positioning by the Golgi apparatus through Rab34 interaction with Rab-interacting lysosomal protein.". Mol. Biol. Cell 13 (12): 4317-32. doi:10.1091/mbc.E02-05-0280. PMID 12475955.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Cardoso C, Leventer RJ, Ward HL, et al. (2003). "Refinement of a 400-kb critical region allows genotypic differentiation between isolated lissencephaly, Miller-Dieker syndrome, and other phenotypes secondary to deletions of 17p13.3.". Am. J. Hum. Genet. 72 (4): 918-30. PMID 12621583.
Harrison RE, Bucci C, Vieira OV, et al. (2003). "Phagosomes fuse with late endosomes and/or lysosomes by extension of membrane protrusions along microtubules: role of Rab7 and RILP.". Mol. Cell. Biol. 23 (18): 6494-506. PMID 12944476.
Wang T, Wong KK, Hong W (2004). "A unique region of RILP distinguishes it from its related proteins in its regulation of lysosomal morphology and interaction with Rab7 and Rab34.". Mol. Biol. Cell 15 (2): 815-26. doi:10.1091/mbc.E03-06-0413. PMID 14668488.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Wan D, Gong Y, Qin W, et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression.". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724-9. doi:10.1073/pnas.0404089101. PMID 15498874.
Wu M, Wang T, Loh E, et al. (2005). "Structural basis for recruitment of RILP by small GTPase Rab7.". EMBO J. 24 (8): 1491-501. doi:10.1038/sj.emboj.7600643. PMID 15933719.
Colucci AM, Campana MC, Bellopede M, Bucci C (2005). "The Rab-interacting lysosomal protein, a Rab7 and Rab34 effector, is capable of self-interaction.". Biochem. Biophys. Res. Commun. 334 (1): 128-33. doi:10.1016/j.bbrc.2005.06.067. PMID 15996637.
Shimojo M, Hersh LB (2006). "Characterization of the REST/NRSF-interacting LIM domain protein (RILP): localization and interaction with REST/NRSF.". J. Neurochem. 96 (4): 1130-8. doi:10.1111/j.1471-4159.2005.03608.x. PMID 16417580.
Marsman M, Jordens I, Rocha N, et al. (2006). "A splice variant of RILP induces lysosomal clustering independent of dynein recruitment.". Biochem. Biophys. Res. Commun. 344 (3): 747-56. doi:10.1016/j.bbrc.2006.03.178. PMID 16631113.
Progida C, Spinosa MR, De Luca A, Bucci C (2006). "RILP interacts with the VPS22 component of the ESCRT-II complex.". Biochem. Biophys. Res. Commun. 347 (4): 1074-9. doi:10.1016/j.bbrc.2006.07.007. PMID 16857164.