RICTOR

From Wikipedia, the free encyclopedia


Rapamycin-insensitive companion of mTOR
Identifiers
Symbol(s) RICTOR; DKFZp686B11164; KIAA1999; MGC39830; mAVO3
External IDs OMIM: 609022 MGI: 1926007 HomoloGene: 34317
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 253260 78757
Ensembl ENSG00000164327 ENSMUSG00000050310
Refseq NM_152756 (mRNA)
NP_689969 (protein)		 NM_030168 (mRNA)
NP_084444 (protein)
Location Chr 5: 38.97 - 39.11 Mb Chr 15: 6.68 - 6.75 Mb
Pubmed search [1] [2]

Rapamycin-insensitive companion of mTOR, also known as RICTOR, is a human gene.[1]

RICTOR and MTOR (FRAP1; MIM 601231) are components of a protein complex that integrates nutrient- and growth factor-derived signals to regulate cell growth (Sarbassov et al., 2004).[supplied by OMIM][1]

[edit] References

  1. ^ a b Entrez Gene: RICTOR rapamycin-insensitive companion of mTOR.

[edit] Further reading

  • Cohen D, Scribner R, Clark J, Cory D (1992). "The potential role of custody facilities in controlling sexually transmitted diseases.". American journal of public health 82 (4): 552-6. PMID 1546771. 
  • Ohara O, Nagase T, Mitsui G, et al. (2003). "Characterization of size-fractionated cDNA libraries generated by the in vitro recombination-assisted method.". DNA Res. 9 (2): 47-57. PMID 12056414. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039. 
  • Sarbassov DD, Ali SM, Kim DH, et al. (2004). "Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton.". Curr. Biol. 14 (14): 1296-302. doi:10.1016/j.cub.2004.06.054. PMID 15268862. 
  • Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130-5. doi:10.1073/pnas.0404720101. PMID 15302935. 
  • Jacinto E, Loewith R, Schmidt A, et al. (2004). "Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive.". Nat. Cell Biol. 6 (11): 1122-8. doi:10.1038/ncb1183. PMID 15467718. 
  • Sarbassov DD, Guertin DA, Ali SM, Sabatini DM (2005). "Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex.". Science 307 (5712): 1098-101. doi:10.1126/science.1106148. PMID 15718470. 
  • Kudchodkar SB, Yu Y, Maguire TG, Alwine JC (2006). "Human cytomegalovirus infection alters the substrate specificities and rapamycin sensitivities of raptor- and rictor-containing complexes.". Proc. Natl. Acad. Sci. U.S.A. 103 (38): 14182-7. doi:10.1073/pnas.0605825103. PMID 16959881. 
  • Jacinto E, Facchinetti V, Liu D, et al. (2006). "SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity.". Cell 127 (1): 125-37. doi:10.1016/j.cell.2006.08.033. PMID 16962653. 
  • Yang Q, Inoki K, Ikenoue T, Guan KL (2006). "Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity.". Genes Dev. 20 (20): 2820-32. doi:10.1101/gad.1461206. PMID 17043309. 
  • Fuchs BC, Finger RE, Onan MC, Bode BP (2007). "ASCT2 silencing regulates mammalian target-of-rapamycin growth and survival signaling in human hepatoma cells.". Am. J. Physiol., Cell Physiol. 293 (1): C55-63. doi:10.1152/ajpcell.00330.2006. PMID 17329400. 
  • Pearce LR, Huang X, Boudeau J, et al. (2007). "Identification of Protor as a novel Rictor-binding component of mTOR complex-2.". Biochem. J. 405 (3): 513-22. doi:10.1042/BJ20070540. PMID 17461779. 
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