Ribosylnicotinamide kinase

From Wikipedia, the free encyclopedia

In enzymology, a ribosylnicotinamide kinase (EC 2.7.1.22) is an enzyme that catalyzes the chemical reaction

ATP + N-ribosylnicotinamide ADP + nicotinamide ribonucleotide

Thus, the two substrates of this enzyme are ATP and N-ribosylnicotinamide, whereas its two products are ADP and nicotinamide ribonucleotide.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:N-ribosylnicotinamide 5'-phosphotransferase. This enzyme is also called ribosylnicotinamide kinase (phosphorylating). This enzyme participates in nicotinate and nicotinamide metabolism.

[edit] References

• IUBMB entry for 2.7.1.22
• BRENDA references for 2.7.1.22 (Recommended.)
• PubMed references for 2.7.1.22
• PubMed Central references for 2.7.1.22
• Google Scholar references for 2.7.1.22
• ROWEN JW, KORNBERG A (1951). "The phosphorolysis of nicotinamide riboside". J. Biol. Chem. 193: 497–507. PMID 14907738. 

[edit] External links

The CAS registry number for this enzyme class is 9030-61-9.

• IUBMB entry for 2.7.1.22

• KEGG entry for 2.7.1.22

• BRENDA entry for 2.7.1.22

• NiceZyme view of 2.7.1.22

• EC2PDB: PDB structures for 2.7.1.22

• PRIAM entry for 2.7.1.22

• PUMA2 entry for 2.7.1.22

• IntEnz: Integrated Enzyme entry for 2.7.1.22

• MetaCyc entry for 2.7.1.22

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0050262: ribosylnicotinamide kinase

• AMIGO entry for GO code 0050262: ribosylnicotinamide kinase