RHOQ

From Wikipedia, the free encyclopedia

Ras homolog gene family, member Q

PDB rendering based on 2atx.

Available structures: 2atx

Identifiers

Symbol(s)

RHOQ; ARHQ; RASL7A; TC10; TC10A

External IDs

OMIM: 605857 MGI: 1931553 HomoloGene: 22704

Gene ontology
Molecular Function:	• nucleotide binding • GTPase activity • protein binding • GTP binding
Cellular Component:	• intracellular • plasma membrane
Biological Process:	• small GTPase mediated signal transduction • biological_process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_012249 (mRNA)
NP_036381 (protein)

NM_145491 (mRNA)
NP_663466 (protein)

Location

Chr 2: 46.62 - 46.66 Mb

Chr 17: 86.87 - 86.91 Mb

Pubmed search

[1]

[2]

Ras homolog gene family, member Q, also known as RHOQ, is a human gene.^[1]

TC10 is a member of the RAS superfamily of small GTP-binding proteins (see HRAS, MIM 190020) involved in insulin-stimulated glucose uptake.[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: RHOQ ras homolog gene family, member Q.

[edit] Further reading

Drivas GT, Shih A, Coutavas E, et al. (1990). "Characterization of four novel ras-like genes expressed in a human teratocarcinoma cell line.". Mol. Cell. Biol. 10 (4): 1793–8. PMID 2108320.
Murphy GA, Solski PA, Jillian SA, et al. (1999). "Cellular functions of TC10, a Rho family GTPase: regulation of morphology, signal transduction and cell growth.". Oncogene 18 (26): 3831–45. doi:10.1038/sj.onc.1202758. PMID 10445846.
Joberty G, Perlungher RR, Macara IG (2000). "The Borgs, a new family of Cdc42 and TC10 GTPase-interacting proteins.". Mol. Cell. Biol. 19 (10): 6585–97. PMID 10490598.
Joberty G, Petersen C, Gao L, Macara IG (2000). "The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42.". Nat. Cell Biol. 2 (8): 531–9. doi:10.1038/35019573. PMID 10934474.
Vignal E, De Toledo M, Comunale F, et al. (2000). "Characterization of TCL, a new GTPase of the rho family related to TC10 andCcdc42.". J. Biol. Chem. 275 (46): 36457–64. doi:10.1074/jbc.M003487200. PMID 10967094.
Michaelson D, Silletti J, Murphy G, et al. (2001). "Differential localization of Rho GTPases in live cells: regulation by hypervariable regions and RhoGDI binding.". J. Cell Biol. 152 (1): 111–26. PMID 11149925.
Neudauer CL, Joberty G, Macara IG (2001). "PIST: a novel PDZ/coiled-coil domain binding partner for the rho-family GTPase TC10.". Biochem. Biophys. Res. Commun. 280 (2): 541–7. doi:10.1006/bbrc.2000.4160. PMID 11162552.
Chiang SH, Hou JC, Hwang J, et al. (2002). "Cloning and functional characterization of related TC10 isoforms, a subfamily of Rho proteins involved in insulin-stimulated glucose transport.". J. Biol. Chem. 277 (15): 13067–73. doi:10.1074/jbc.M109471200. PMID 11821390.
Kanzaki M, Watson RT, Hou JC, et al. (2003). "Small GTP-binding protein TC10 differentially regulates two distinct populations of filamentous actin in 3T3L1 adipocytes.". Mol. Biol. Cell 13 (7): 2334–46. doi:10.1091/mbc.01-10-0490. PMID 12134073.
Chang L, Adams RD, Saltiel AR (2002). "The TC10-interacting protein CIP4/2 is required for insulin-stimulated Glut4 translocation in 3T3L1 adipocytes.". Proc. Natl. Acad. Sci. U.S.A. 99 (20): 12835–40. doi:10.1073/pnas.202495599. PMID 12242347.
Abe T, Kato M, Miki H, et al. (2003). "Small GTPase Tc10 and its homologue RhoT induce N-WASP-mediated long process formation and neurite outgrowth.". J. Cell. Sci. 116 (Pt 1): 155–68. PMID 12456725.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Heilig R, Eckenberg R, Petit JL, et al. (2003). "The DNA sequence and analysis of human chromosome 14.". Nature 421 (6923): 601–7. doi:10.1038/nature01348. PMID 12508121.
Watson RT, Furukawa M, Chiang SH, et al. (2003). "The exocytotic trafficking of TC10 occurs through both classical and nonclassical secretory transport pathways in 3T3L1 adipocytes.". Mol. Cell. Biol. 23 (3): 961–74. PMID 12529401.
Inoue M, Chang L, Hwang J, et al. (2003). "The exocyst complex is required for targeting of Glut4 to the plasma membrane by insulin.". Nature 422 (6932): 629–33. doi:10.1038/nature01533. PMID 12687004.
Chunqiu Hou J, Pessin JE (2004). "Lipid Raft targeting of the TC10 amino terminal domain is responsible for disruption of adipocyte cortical actin.". Mol. Biol. Cell 14 (9): 3578–91. doi:10.1091/mbc.E03-01-0012. PMID 12972548.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Ng Y, Tan I, Lim L, Leung T (2004). "Expression of the human myotonic dystrophy kinase-related Cdc42-binding kinase gamma is regulated by promoter DNA methylation and Sp1 binding.". J. Biol. Chem. 279 (33): 34156–64. doi:10.1074/jbc.M405252200. PMID 15194684.
Ruusala A, Aspenström P (2004). "Isolation and characterisation of DOCK8, a member of the DOCK180-related regulators of cell morphology.". FEBS Lett. 572 (1-3): 159–66. doi:10.1016/j.febslet.2004.06.095. PMID 15304341.
Nalbant P, Hodgson L, Kraynov V, et al. (2004). "Activation of endogenous Cdc42 visualized in living cells.". Science 305 (5690): 1615–9. doi:10.1126/science.1100367. PMID 15361624.