RHEB

From Wikipedia, the free encyclopedia

Ras homolog enriched in brain

PDB rendering based on 1xtq.

Available structures: 1xtq, 1xtr, 1xts

Identifiers

Symbol(s)

RHEB; MGC111559; RHEB2

External IDs

OMIM: 601293 MGI: 97912 HomoloGene: 4101

Gene ontology
Molecular Function:	• nucleotide binding • GTPase activity • GTP binding
Cellular Component:	• intracellular • spliceosome • membrane
Biological Process:	• signal transduction • small GTPase mediated signal transduction

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_005614 (mRNA)
NP_005605 (protein)

XM_982185 (mRNA)
XP_987279 (protein)

Location

Chr 7: 150.79 - 150.85 Mb

Chr 5: 24.31 - 24.33 Mb

Pubmed search

[1]

[2]

Ras homolog enriched in brain, also known as RHEB, is a human gene.

This gene is a member of the small GTPase superfamily and encodes a lipid-anchored, cell membrane protein with five repeats of the RAS-related GTP-binding region. This protein is vital in regulation of growth and cell cycle progression due to its role in the insulin/TOR/S6K signaling pathway. The protein has GTPase activity and shuttles between a GDP-bound form and a GTP-bound form, and farnesylation of the protein is required for this activity. Three pseudogenes have been mapped, two on chromosome 10 and one on chromosome 22.^[1]

[edit] References

^ Entrez Gene: RHEB Ras homolog enriched in brain.

[edit] Further reading

Yamagata K, Sanders LK, Kaufmann WE, et al. (1994). "rheb, a growth factor- and synaptic activity-regulated gene, encodes a novel Ras-related protein.". J. Biol. Chem. 269 (23): 16333–9. PMID 8206940.
Gromov PS, Madsen P, Tomerup N, Celis JE (1996). "A novel approach for expression cloning of small GTPases: identification, tissue distribution and chromosome mapping of the human homolog of rheb.". FEBS Lett. 377 (2): 221–6. PMID 8543055.
Mizuki N, Kimura M, Ohno S, et al. (1996). "Isolation of cDNA and genomic clones of a human Ras-related GTP-binding protein gene and its chromosomal localization to the long arm of chromosome 7, 7q36.". Genomics 34 (1): 114–8. PMID 8661031.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. PMID 8889548.
Yee WM, Worley PF (1997). "Rheb interacts with Raf-1 kinase and may function to integrate growth factor- and protein kinase A-dependent signals.". Mol. Cell. Biol. 17 (2): 921–33. PMID 9001246.
Clark GJ, Kinch MS, Rogers-Graham K, et al. (1997). "The Ras-related protein Rheb is farnesylated and antagonizes Ras signaling and transformation.". J. Biol. Chem. 272 (16): 10608–15. PMID 9099708.
Inohara N, Ding L, Chen S, Núñez G (1997). "harakiri, a novel regulator of cell death, encodes a protein that activates apoptosis and interacts selectively with survival-promoting proteins Bcl-2 and Bcl-X(L).". EMBO J. 16 (7): 1686–94. doi:10.1093/emboj/16.7.1686. PMID 9130713.
"Toward a complete human genome sequence." (1999). Genome Res. 8 (11): 1097–108. PMID 9847074.
Kita K, Wu YP, Sugaya S, et al. (2000). "Search for UV-responsive genes in human cells by differential mRNA display: involvement of human ras-related GTP-binding protein, Rheb, in UV susceptibility.". Biochem. Biophys. Res. Commun. 274 (3): 859–64. doi:10.1006/bbrc.2000.3220. PMID 10924367.
Hanzal-Bayer M, Renault L, Roversi P, et al. (2002). "The complex of Arl2-GTP and PDE delta: from structure to function.". EMBO J. 21 (9): 2095–106. doi:10.1093/emboj/21.9.2095. PMID 11980706.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology.". Science 300 (5620): 767–72. doi:10.1126/science.1083423. PMID 12690205.
Zhang Y, Gao X, Saucedo LJ, et al. (2003). "Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins.". Nat. Cell Biol. 5 (6): 578–81. doi:10.1038/ncb999. PMID 12771962.
Garami A, Zwartkruis FJ, Nobukuni T, et al. (2003). "Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2.". Mol. Cell 11 (6): 1457–66. PMID 12820960.
Castro AF, Rebhun JF, Clark GJ, Quilliam LA (2003). "Rheb binds tuberous sclerosis complex 2 (TSC2) and promotes S6 kinase activation in a rapamycin- and farnesylation-dependent manner.". J. Biol. Chem. 278 (35): 32493–6. doi:10.1074/jbc.C300226200. PMID 12842888.
Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7.". Nature 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.
Tabancay AP, Gau CL, Machado IM, et al. (2003). "Identification of dominant negative mutants of Rheb GTPase and their use to implicate the involvement of human Rheb in the activation of p70S6K.". J. Biol. Chem. 278 (41): 39921–30. doi:10.1074/jbc.M306553200. PMID 12869548.
Inoki K, Li Y, Xu T, Guan KL (2003). "Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling.". Genes Dev. 17 (15): 1829–34. doi:10.1101/gad.1110003. PMID 12869586.
Tee AR, Manning BD, Roux PP, et al. (2004). "Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb.". Curr. Biol. 13 (15): 1259–68. PMID 12906785.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.