RGS7

From Wikipedia, the free encyclopedia

Regulator of G-protein signalling 7

PDB rendering based on 2a72.

Available structures: 2a72, 2d9j

Identifiers

Symbol(s)

RGS7;

External IDs

OMIM: 602517 MGI: 1346089 HomoloGene: 2193

Gene ontology
Molecular Function:	• signal transducer activity • regulator of G-protein signaling activity
Cellular Component:	• cellular_component • heterotrimeric G-protein complex
Biological Process:	• G-protein coupled receptor protein signaling pathway • intracellular signaling cascade • regulation of G-protein coupled receptor protein signaling pathway • negative regulation of signal transduction

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_002924 (mRNA)
NP_002915 (protein)

NM_011880 (mRNA)
NP_036010 (protein)

Location

Chr 1: 239.01 - 239.59 Mb

Chr 1: 176.9 - 177.33 Mb

Pubmed search

[1]

[2]

Regulator of G-protein signalling 7, also known as RGS7, is a human gene.^[1]

[edit] References

^ Entrez Gene: RGS7 regulator of G-protein signalling 7.

[edit] Further reading

Koelle MR, Horvitz HR (1996). "EGL-10 regulates G protein signaling in the C. elegans nervous system and shares a conserved domain with many mammalian proteins.". Cell 84 (1): 115–25. PMID 8548815.
Shuey DJ, Betty M, Jones PG, et al. (1998). "RGS7 attenuates signal transduction through the G(alpha q) family of heterotrimeric G proteins in mammalian cells.". J. Neurochem. 70 (5): 1964–72. PMID 9572280.
Levay K, Cabrera JL, Satpaev DK, Slepak VZ (1999). "Gbeta5 prevents the RGS7-Galphao interaction through binding to a distinct Ggamma-like domain found in RGS7 and other RGS proteins.". Proc. Natl. Acad. Sci. U.S.A. 96 (5): 2503–7. PMID 10051672.
Saitoh O, Kubo Y, Odagiri M, et al. (1999). "RGS7 and RGS8 differentially accelerate G protein-mediated modulation of K+ currents.". J. Biol. Chem. 274 (14): 9899–904. PMID 10092682.
Kim E, Arnould T, Sellin L, et al. (1999). "Interaction between RGS7 and polycystin.". Proc. Natl. Acad. Sci. U.S.A. 96 (11): 6371–6. PMID 10339594.
Snow BE, Betts L, Mangion J, et al. (1999). "Fidelity of G protein beta-subunit association by the G protein gamma-subunit-like domains of RGS6, RGS7, and RGS11.". Proc. Natl. Acad. Sci. U.S.A. 96 (11): 6489–94. PMID 10339615.
Posner BA, Gilman AG, Harris BA (1999). "Regulators of G protein signaling 6 and 7. Purification of complexes with gbeta5 and assessment of their effects on g protein-mediated signaling pathways.". J. Biol. Chem. 274 (43): 31087–93. PMID 10521509.
Benzing T, Yaffe MB, Arnould T, et al. (2000). "14-3-3 interacts with regulator of G protein signaling proteins and modulates their activity.". J. Biol. Chem. 275 (36): 28167–72. doi:10.1074/jbc.M002905200. PMID 10862767.
Rose JJ, Taylor JB, Shi J, et al. (2000). "RGS7 is palmitoylated and exists as biochemically distinct forms.". J. Neurochem. 75 (5): 2103–12. PMID 11032900.
Zhang JH, Barr VA, Mo Y, et al. (2001). "Nuclear localization of G protein beta 5 and regulator of G protein signaling 7 in neurons and brain.". J. Biol. Chem. 276 (13): 10284–9. doi:10.1074/jbc.M009247200. PMID 11152459.
Benzing T, Köttgen M, Johnson M, et al. (2002). "Interaction of 14-3-3 protein with regulator of G protein signaling 7 is dynamically regulated by tumor necrosis factor-alpha.". J. Biol. Chem. 277 (36): 32954–62. doi:10.1074/jbc.M200859200. PMID 12077120.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Hunt RA, Edris W, Chanda PK, et al. (2003). "Snapin interacts with the N-terminus of regulator of G protein signaling 7.". Biochem. Biophys. Res. Commun. 303 (2): 594–9. PMID 12659861.
Witherow DS, Tovey SC, Wang Q, et al. (2003). "G beta 5.RGS7 inhibits G alpha q-mediated signaling via a direct protein-protein interaction.". J. Biol. Chem. 278 (23): 21307–13. doi:10.1074/jbc.M212884200. PMID 12670932.
Anderson NL, Polanski M, Pieper R, et al. (2004). "The human plasma proteome: a nonredundant list developed by combination of four separate sources.". Mol. Cell Proteomics 3 (4): 311–26. doi:10.1074/mcp.M300127-MCP200. PMID 14718574.
Takida S, Fischer CC, Wedegaertner PB (2005). "Palmitoylation and plasma membrane targeting of RGS7 are promoted by alpha o.". Mol. Pharmacol. 67 (1): 132–9. doi:10.1124/mol.104.003418. PMID 15496508.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
Drenan RM, Doupnik CA, Jayaraman M, et al. (2006). "R7BP augments the function of RGS7*Gbeta5 complexes by a plasma membrane-targeting mechanism.". J. Biol. Chem. 281 (38): 28222–31. doi:10.1074/jbc.M604428200. PMID 16867977.