RGN (gene)

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Regucalcin (senescence marker protein-30)
Identifiers
Symbol(s) RGN; RC; SMP30
External IDs OMIM: 300212 MGI: 108024 HomoloGene: 3437
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 9104 19733
Ensembl ENSG00000130988 ENSMUSG00000023070
Uniprot Q15493 Q3UJG3
Refseq XM_001126531 (mRNA)
XP_001126531 (protein)		 NM_009060 (mRNA)
NP_033086 (protein)
Location Chr X: 46.82 - 46.84 Mb Chr X: 19.71 - 19.72 Mb
Pubmed search [1] [2]

Regucalcin (senescence marker protein-30), also known as RGN, is a human gene.[1]

The protein encoded by this gene is a highly conserved, calcium-binding protein, that is preferentially expressed in the liver and kidney. It may have an important role in calcium homeostasis. Studies in rat indicate that this protein may also play a role in aging, as it shows age-associated down-regulation. This gene is part of a gene cluster on chromosome Xp11.3-Xp11.23. Alternative splicing results in two transcript variants having different 5' UTRs, but encoding the same protein.[1]

[edit] References

  1. ^ a b Entrez Gene: RGN regucalcin (senescence marker protein-30).

[edit] Further reading

  • Fujita T, Shirasawa T, Maruyama N (1999). "Expression and structure of senescence marker protein-30 (SMP30) and its biological significance.". Mech. Ageing Dev. 107 (3): 271–80. PMID 10360682. 
  • Fujita T, Mandel JL, Shirasawa T, et al. (1995). "Isolation of cDNA clone encoding human homologue of senescence marker protein-30 (SMP30) and its location on the X chromosome.". Biochim. Biophys. Acta 1263 (3): 249–52. PMID 7548213. 
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149. 
  • Misawa H, Yamaguchi M (2000). "Transcript heterogeneity of the human gene for Ca2+-binding protein regucalcin.". Int. J. Mol. Med. 5 (3): 283–7. PMID 10677570. 
  • Thiselton DL, McDowall J, Brandau O, et al. (2002). "An integrated, functionally annotated gene map of the DXS8026-ELK1 interval on human Xp11.3-Xp11.23: potential hotspot for neurogenetic disorders.". Genomics 79 (4): 560–72. doi:10.1006/geno.2002.6733. PMID 11944989. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Ishigami A, Handa S, Maruyama N, Supakar PC (2003). "Nuclear localization of senescence marker protein-30, SMP30, in cultured mouse hepatocytes and its similarity to RNA polymerase.". Biosci. Biotechnol. Biochem. 67 (1): 158–60. PMID 12619687. 
  • Matsuyama S, Kitamura T, Enomoto N, et al. (2004). "Senescence marker protein-30 regulates Akt activity and contributes to cell survival in Hep G2 cells.". Biochem. Biophys. Res. Commun. 321 (2): 386–90. doi:10.1016/j.bbrc.2004.06.161. PMID 15358188. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Warizaya M, Kinoshita T, Yamaoka M, et al. (2005). "Expression, purification, crystallization and preliminary X-ray diffraction studies of human liver regucalcin.". Acta Crystallogr. D Biol. Crystallogr. 60 (Pt 11): 2019–21. doi:10.1107/S0907444904020608. PMID 15502314. 
  • Ishigami A, Fujita T, Inoue H, et al. (2005). "Senescence marker protein-30 (SMP30) induces formation of microvilli and bile canaliculi in Hep G2 cells.". Cell Tissue Res. 320 (2): 243–9. doi:10.1007/s00441-004-1073-5. PMID 15714273. 
  • Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome.". Nature 434 (7031): 325–37. doi:10.1038/nature03440. PMID 15772651. 
  • Yamaguchi M, Daimon Y (2005). "Overexpression of regucalcin suppresses cell proliferation in cloned rat hepatoma H4-II-E cells: involvement of intracellular signaling factors and cell cycle-related genes.". J. Cell. Biochem. 95 (6): 1169–77. doi:10.1002/jcb.20490. PMID 15962315. 
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