RFC4

From Wikipedia, the free encyclopedia

Replication factor C (activator 1) 4, 37kDa

Identifiers

RFC4; A1; MGC27291; RFC37

External IDs

OMIM: 102577 MGI: 2146571 HomoloGene: 6288

Gene ontology
Molecular Function:	• nucleotide binding • protein binding • ATP binding • nucleoside-triphosphatase activity
Cellular Component:	• nucleus • DNA replication factor C complex
Biological Process:	• DNA replication • DNA strand elongation during DNA replication • DNA repair • phosphoinositide-mediated signaling

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_002916 (mRNA)
NP_002907 (protein)

NM_145480 (mRNA)
NP_663455 (protein)

Location

Chr 3: 187.99 - 188.01 Mb

Chr 16: 23.03 - 23.04 Mb

Pubmed search

[1]

[2]

Replication factor C (activator 1) 4, 37kDa, also known as RFC4, is a human gene.^[1]

The elongation of primed DNA templates by DNA polymerase delta and DNA polymerase epsilon requires the accessory proteins proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also named activator 1, is a protein complex consisting of five distinct subunits of 140, 40, 38, 37, and 36 kD. This gene encodes the 37 kD subunit. This subunit forms a core complex with the 36 and 40 kDa subunits. The core complex possesses DNA-dependent ATPase activity, which was found to be stimulated by PCNA in an in vitro system. Alternatively spliced transcript variants encoding the same protein have been reported.^[1]

[edit] References

^ ^a ^b Entrez Gene: RFC4 replication factor C (activator 1) 4, 37kDa.

[edit] Further reading

Chen M, Pan ZQ, Hurwitz J (1992). "Studies of the cloned 37-kDa subunit of activator 1 (replication factor C) of HeLa cells.". Proc. Natl. Acad. Sci. U.S.A. 89 (12): 5211–5. PMID 1351677.
Okumura K, Nogami M, Taguchi H, et al. (1995). "Assignment of the 36.5-kDa (RFC5), 37-kDa (RFC4), 38-kDa (RFC3), and 40-kDa (RFC2) subunit genes of human replication factor C to chromosome bands 12q24.2-q24.3, 3q27, 13q12.3-q13, and 7q11.23.". Genomics 25 (1): 274–8. PMID 7774928.
Uhlmann F, Cai J, Flores-Rozas H, et al. (1996). "In vitro reconstitution of human replication factor C from its five subunits.". Proc. Natl. Acad. Sci. U.S.A. 93 (13): 6521–6. PMID 8692848.
Cujec TP, Cho H, Maldonado E, et al. (1997). "The human immunodeficiency virus transactivator Tat interacts with the RNA polymerase II holoenzyme.". Mol. Cell. Biol. 17 (4): 1817–23. PMID 9121429.
Cai J, Gibbs E, Uhlmann F, et al. (1997). "A complex consisting of human replication factor C p40, p37, and p36 subunits is a DNA-dependent ATPase and an intermediate in the assembly of the holoenzyme.". J. Biol. Chem. 272 (30): 18974–81. PMID 9228079.
Loor G, Zhang SJ, Zhang P, et al. (1998). "Identification of DNA replication and cell cycle proteins that interact with PCNA.". Nucleic Acids Res. 25 (24): 5041–6. PMID 9396813.
Ellison V, Stillman B (1998). "Reconstitution of recombinant human replication factor C (RFC) and identification of an RFC subcomplex possessing DNA-dependent ATPase activity.". J. Biol. Chem. 273 (10): 5979–87. PMID 9488738.
Zhang G, Gibbs E, Kelman Z, et al. (1999). "Studies on the interactions between human replication factor C and human proliferating cell nuclear antigen.". Proc. Natl. Acad. Sci. U.S.A. 96 (5): 1869–74. PMID 10051561.
Uchiumi F, Watanabe M, Tanuma S (1999). "Characterization of telomere-binding activity of replication factor C large subunit p140.". Biochem. Biophys. Res. Commun. 258 (2): 482–9. PMID 10329413.
van der Kuip H, Carius B, Haque SJ, et al. (1999). "The DNA-binding subunit p140 of replication factor C is upregulated in cycling cells and associates with G1 phase cell cycle regulatory proteins.". J. Mol. Med. 77 (4): 386–92. PMID 10353443.
Chaib H, Cockrell EK, Rubin MA, Macoska JA (2001). "Profiling and verification of gene expression patterns in normal and malignant human prostate tissues by cDNA microarray analysis.". Neoplasia 3 (1): 43–52. doi:10.1038/sj/neo/7900126. PMID 11326315.
Naiki T, Kondo T, Nakada D, et al. (2001). "Chl12 (Ctf18) forms a novel replication factor C-related complex and functions redundantly with Rad24 in the DNA replication checkpoint pathway.". Mol. Cell. Biol. 21 (17): 5838–45. PMID 11486023.
Lindsey-Boltz LA, Bermudez VP, Hurwitz J, Sancar A (2001). "Purification and characterization of human DNA damage checkpoint Rad complexes.". Proc. Natl. Acad. Sci. U.S.A. 98 (20): 11236–41. doi:10.1073/pnas.201373498. PMID 11572977.
Griffith JD, Lindsey-Boltz LA, Sancar A (2002). "Structures of the human Rad17-replication factor C and checkpoint Rad 9-1-1 complexes visualized by glycerol spray/low voltage microscopy.". J. Biol. Chem. 277 (18): 15233–6. doi:10.1074/jbc.C200129200. PMID 11907025.
Anderson LA, Perkins ND (2002). "The large subunit of replication factor C interacts with the histone deacetylase, HDAC1.". J. Biol. Chem. 277 (33): 29550–4. doi:10.1074/jbc.M200513200. PMID 12045192.
Ohta S, Shiomi Y, Sugimoto K, et al. (2002). "A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein.". J. Biol. Chem. 277 (43): 40362–7. doi:10.1074/jbc.M206194200. PMID 12171929.
Maruyama T, Farina A, Dey A, et al. (2002). "A Mammalian bromodomain protein, brd4, interacts with replication factor C and inhibits progression to S phase.". Mol. Cell. Biol. 22 (18): 6509–20. PMID 12192049.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Anderson LA, Perkins ND (2003). "Regulation of RelA (p65) function by the large subunit of replication factor C.". Mol. Cell. Biol. 23 (2): 721–32. PMID 12509469.
Nagata T, Takahashi Y, Ishii Y, et al. (2004). "Profiling of genes differentially expressed between fetal liver and postnatal liver using high-density oligonucleotide DNA array.". Int. J. Mol. Med. 11 (6): 713–21. PMID 12736711.