Reticulon 4 receptor

From Wikipedia, the free encyclopedia

PDB rendering based on 1ozn.

Available structures: 1ozn, 1p8t

Identifiers

Symbol(s)

RTN4R; NGR; NOGOR

External IDs

OMIM: 605566 MGI: 2136886 HomoloGene: 11299

Gene ontology
Molecular Function:	• receptor activity • protein binding • GPI anchor binding
Cellular Component:	• endoplasmic reticulum • plasma membrane
Biological Process:	• axonogenesis

Orthologs

Human

Mouse

Refseq

NM_023004 (mRNA)
NP_075380 (protein)

NM_022982 (mRNA)
NP_075358 (protein)

Location

Chr 22: 18.61 - 18.64 Mb

Chr 16: 18.06 - 18.07 Mb

Pubmed search

[1]

[2]

Reticulon 4 receptor, also known as RTN4R, is a human gene.^[1]

This gene encodes the receptor for reticulon 4, oligodendrocyte myelin glycoprotein and myelin-associated glycoprotein. This receptor mediates axonal growth inhibition and may play a role in regulating axonal regeneration and plasticity in the adult central nervous system.^[1]

[edit] See also

Reticulon 4

[edit] References

^ ^a ^b Entrez Gene: RTN4R reticulon 4 receptor.

[edit] Further reading

Ng CE, Tang BL (2002). "Nogos and the Nogo-66 receptor: factors inhibiting CNS neuron regeneration.". J. Neurosci. Res. 67 (5): 559–65. PMID 11891768.
Ferraro GB (2007). "Refining our understanding of NgR1 function during myelin inhibition.". J. Neurosci. 27 (43): 11451–2. doi:10.1523/JNEUROSCI.3419-07.2007. PMID 17959786.
Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22.". Nature 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. PMID 11076863.
Fournier AE, GrandPre T, Strittmatter SM (2001). "Identification of a receptor mediating Nogo-66 inhibition of axonal regeneration.". Nature 409 (6818): 341–6. doi:10.1038/35053072. PMID 11201742.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. doi:10.1101/gr.154701. PMID 11230166.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMID 11256614.
GrandPré T, Li S, Strittmatter SM (2002). "Nogo-66 receptor antagonist peptide promotes axonal regeneration.". Nature 417 (6888): 547–51. doi:10.1038/417547a. PMID 12037567.
Wang KC, Koprivica V, Kim JA, et al. (2002). "Oligodendrocyte-myelin glycoprotein is a Nogo receptor ligand that inhibits neurite outgrowth.". Nature 417 (6892): 941–4. doi:10.1038/nature00867. PMID 12068310.
Liu BP, Fournier A, GrandPré T, Strittmatter SM (2002). "Myelin-associated glycoprotein as a functional ligand for the Nogo-66 receptor.". Science 297 (5584): 1190–3. doi:10.1126/science.1073031. PMID 12089450.
Domeniconi M, Cao Z, Spencer T, et al. (2002). "Myelin-associated glycoprotein interacts with the Nogo66 receptor to inhibit neurite outgrowth.". Neuron 35 (2): 283–90. PMID 12160746.
Woolf CJ, Bloechlinger S (2002). "Neuroscience. It takes more than two to Nogo.". Science 297 (5584): 1132–4. doi:10.1126/science.1076247. PMID 12183616.
Josephson A, Trifunovski A, Widmer HR, et al. (2002). "Nogo-receptor gene activity: cellular localization and developmental regulation of mRNA in mice and humans.". J. Comp. Neurol. 453 (3): 292–304. doi:10.1002/cne.10408. PMID 12378589.
Wang KC, Kim JA, Sivasankaran R, et al. (2002). "P75 interacts with the Nogo receptor as a co-receptor for Nogo, MAG and OMgp.". Nature 420 (6911): 74–8. doi:10.1038/nature01176. PMID 12422217.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
He XL, Bazan JF, McDermott G, et al. (2003). "Structure of the Nogo receptor ectodomain: a recognition module implicated in myelin inhibition.". Neuron 38 (2): 177–85. PMID 12718853.
Barton WA, Liu BP, Tzvetkova D, et al. (2003). "Structure and axon outgrowth inhibitor binding of the Nogo-66 receptor and related proteins.". EMBO J. 22 (13): 3291–302. doi:10.1093/emboj/cdg325. PMID 12839991.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.